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Optical multilayer optimization continuously reorganizes layer 0-1-2 network elements to handle both existing and dynamic traffic requirements in the most efficient manner. This delays the need to add new resources for new requests, saving CAPEX and leads to optical network defragmentation. The focus of this paper is on Layer 2, i.e., on capacity defragmentation at the OTN layer when routes (e.g., LSPs in MPLS networks) are making unnecessarily long detours to evade congestion. Reconfiguration into optimized routes can be achieved by redefining the routes, one at a time, so that they use the vacant resources generated by the disappearance of services using part of a path that transits the congested section. For the Quality of Service, it is desirable to operate under Make Before Break (MBB), with the minimum number of rerouting. The challenge is to identify the rerouting order, one connection at a time, while minimizing the bandwidth requirement. We propose an exact and scalable optimization model for computing a minimum bandwidth rerouting scheme subject to MBB in the OTN layer of an optical network. Numerical results show that we can successfully apply it on networks with up to 30 nodes, a very significant improvement with the state of the art. We also provide some defragmentation analysis in terms of the bandwidth requirement vs. the number of reroutings.

A maximum adsorption capacity of 811.7 mg g−1 was achieved for RhB onto BUT-8(Cr).

(1) Background: In Vietnam, H. pylori bacteria has a resistance rate of 63% to the antibiotic clarithromycin. The initial therapy of H. pylori eradication with a standard three-drug regimen has low efficacy. Objective: Assess the efficacy of H. pylori eradication therapy which uses a four-drug regimen of rabeprazole–bismuth–tetracycline–tinidazole in patients with duodenal ulcers. (2) Methods: We performed gastrointestinal endoscopy on patients with a diagnosis of duodenal ulcers, gastric mucosa biopsy for a rapid urease test, and histopathology to diagnose H. pylori bacteria before and after treatment. Treatment for eradication of H. pylori bacteria using a rabeprazole–bismuth–tetracycline–tinidazole regimen was prescribed for 14 days. (3) Results: The rate of successful H. pylori eradication treatment according to per protocol (PP) and intention to treat (ITT) was 91.3% (95%CI: 84.8–96.7) and 82.4% (95%CI: 74.5–89.2) respectively. The success rate of H. pylori eradication therapy in males was 96.0% (95%CI: 92–100), higher than in females, which was 70.6% (95%CI: 47.1–88.2), p < 0.01. (4) Conclusions: Treatment of H. pylori with rabeprazole–bismuth–tetracycline–tinidazole regimen is highly effective. Men had higher H. pylori eradication results than women.

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