The THO complex is an evolutionary conserved multi-subunit protein complex. Although its role in the formation of exportcompetent messenger ribonucleoproteins (mRNPs) is well established at the single cell level, it is still largely unknown about its specific roles at the multi-cellular organism level.Here we show that Drosophila THO complex is required for normal life span and environmental stress response. Mutant flies defective in the THO complex showed increased susceptibility to certain environmental stresses as well as shortened life span. The increased susceptibility to the environmental stress was suppressed by up-regulating c-Jun N-terminal kinase (JNK) signaling, which is a key regulator of environmental stress resistance and longevity. In addition to this, the expression of Drosophila eIF4E binding protein (4E-BP), a target of JNK in stress response, was mis-regulated at the post-transcriptional level in the THO mutants. Taken together, our data suggested that Drosophila THO complex may participate in the environmental stress response by regulating the expression of certain JNK-mediated stress-responsible genes.

Self-assembly of ZnX 2 (X = Cl, Br, and I) with 2,7-bis(nicotinoyloxy)naphthalene (L) as a hemicircular bidentate ligand containing a chromophore moiety yields a systematic metallacyclodimeric unit, [ZnX 2 (L)] 2 . These basic skeletons constitute, via interdigitated π•••π interactions, a unique columnar ensemble forming a suprachannel. This can then be employed as an unusual "diiodomethane within the suprachannel" host−guest system, CH 2 I 2 @[ZnX 2 (L)] 2 . Specifically, the suprachannel significantly stabilizes the CH 2 I 2 molecules in the order [ZnI 2 (L)] 2 > [ZnBr 2 (L)] 2 > [ZnCl 2 (L)] 2 . This suprachannel has significant halogen effects on the photoluminescence (PL), thermal properties, and host−guest inclusion.

Infinite rectangular-tubular helices, [MX2L] (M = Zn(ii), Hg(ii); X(-) = Cl(-), Br(-); L = bis(3-pyridyl)cyclotetramethylenesilane), have been efficiently constructed via the combined effects of the potential flexible conformers of L and the tetrahedral geometry of M(ii) ions. This helical molecular system affords a racemic mixture of P- and M-helices in a crystal. The helical pitches (7.8934(4)-8.1560(2) Å) that are sensitive to the nature of M(ii) ions and halide anions are attributable to subtle change in the flexible dihedral angles between the two pyridyl groups around Si and the M(ii) hinges. Their photoluminescence intensities, correspondingly, are in the order [ZnCl2L] > [ZnBr2L] ≫ [HgCl2L] > [HgBr2L]. Zinc(ii) complexes show recyclable catalytic effects on the transesterification reaction in the order [ZnCl2L] > [ZnBr2L]. Calcination of [ZnCl2L] and [ZnBr2L] at 500 °C produces uniform hexagonal tubular spire crystals of 1.2 × 1.2 × 4.0 μm(3) dimensions and spheres, respectively.

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