No abstract

An acute experiment involving the suppressing of the lipolytic activity of human growth hormone (HGH) with sheep acetyl prolactin has been carried out. The experiment is based on the similarity of the physicochemical properties of native sheep prolactin and human somatotrophin. The derivative obtained inhibits the lipolytic activity of HGH to the same extent as acetylated and iodinated human somatotrophin. Similarly modified albumin and casein appear to produce no inhibitory effect, thus revealing the specific character of the anti-hormonal effect of hormone derivatives obtained. There is good reason for believing that acetylated sheep prolactin (anaprolactin) is a competing anahormone. The data on three types of anahormones are discussed.

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The effect of experimental hyperlipidemia on functional activity of macrophages was studied in CBA and C57Bl/6 mice resistant and sensitive to the formation of aorta lesions, respectively. Two-month atherogenic diet increased the content of cholesterol in the serum and cells of peritoneal exudate in mice of both strains. In parallel, production of nitrites and 5'-nucleotidase activity in peritoneal macrophages increased, while parameters of phagocytosis, pinocytosis, and NBT test remained unchanged. Changes in the state of macrophages can be explained by increased cholesterol content. The absence of differences in functional activity of macrophages in CBA and C57Bl/6 mice indicates that the observed shifts are insignificant for the development of fatty streaks in the aorta.