Latar belakang: Prevalesi kanker kulit semakin meningkat di seluruh dunia. Walaupun insiden tertinggi pada kelompok berkulit putih, namun mengetahui epidemiologi dan tren penyakit dari kanker kulit diperlukan agar dapat menentukan pencegahan dan penanganan yang tepat. Tujuan: Untuk mengetahui karakteristik kanker kulit pada pasien yang telah dilakukan skin flap di Departemen Dermatologi dan Venereologi RSUP Sanglah. Metode: Penelitian ini merupakan studi deskriptif retrospektif dari catatan medis semua penderita kanker kulit yang memperoleh tindakan skin flap sejak Januari 2015 sampai dengan Desember 2019. Sampel diambil melalui total sampling. Karakteristik yang tercatat meliputi jenis kanker, jenis kelamin, umur, tipe kulit, pekerjaan, dan jenis flap yang dilakukan. Data yang terkumpul dianalisis secara deskriptif dengan program SPSS Ver21. Hasil: Terdapat 41 pasien kanker kulit yang memperoleh tindakan skin flap, terdiri dari 43,9% (n=16) BCC, 54,6% (n=10) melanoma, 21,9% (n=9) SCC, 9,8% (n=4) jenis kanker lain. Jenis flap yang umum digunakan yaitu simple advancement. Lokasi kanker paling umum ditemukan pada wajah dan kejadian kanker paling tinggi terjadi pada usia ≥50 tahun dan bekerja di luar ruangan. Simpulan: Kasus kanker tertinggi yaitu BCC dengan usia lebih dari 50 tahun dan bekerja di luar ruangan sebagai karakteristik paling umum pada semua kasus kanker.

Background: Basal cell carcinoma (BCC) has a very slow-growing and rarely metastatic nature but tends to be locally invasive and relapse after therapy. Elliptical excision is one of the surgical procedures in the field of dermatology which is most often used with the application of tumescent techniques. Case Description: A woman, 64 years old, no. CM. 18.03.11.71, Balinese tribe, on July 30, 2018, came to the Dermatology and Venerology Polyclinic at Sanglah General Hospital with a frequent symptom of arising from wounds on the forehead. The lession Latar Belakang: Karsinoma sel basal (KSB) memiliki sifat tumbuh dan berkembang sangat lambat dan jarang metastasis, namun memiliki kecenderungan invasif lokal dan kambuh setelah dilakukan terapi. Eksisi elips merupakan salah satu prosedur bedah dalam bidang dermatologi yang paling sering digunakan dengan aplikasi teknik tumesen. Deskripsi Kasus: Seorang perempuan, 64 tahun, no. CM. 18.03.11.71, suku Bali, pada tanggal 30 Juli 2018 datang ke Poliklinik Kulit dan Kelamin Rumah Sakit Sanglah dengan keluhan utama timbul luka pada dahi. Luka tersebut mulai timbul sejak began one year ago. Initially, it was a small reddish lump which was then felt more and more dilated as well as became blackish and accompanied by itching. Dermatology examination revealed hyperpigmentation, solitary, oval, 3x2cm, multiple erosion, firm boundary, round shape, 0.3-0.4 cm in diameter, covered in black crusting on top. Conclusion: The diagnosis of BCC determined on anamnesis, physical examination, dermoscopy, and histopathology regard with standard ellipse excision surgery. 1 tahun yang lalu. Awalnya lesi berupa benjolan kecil berwarna kemerahan yang kemudian makin lama dirasakan makin melebar dan menjadi berwarna kehitaman serta disertai rasa gatal. Pemeriksaan dermatologi pada lokasi dahi (frontalis) tampak plak hiperpigmentasi, soliter, bentuk oval, ukuran 3x2cm, tampak erosi multiple, batas tegas, bentuk bulat, ukuran diameter 0,3-0,4 cm, ditutupi krusta kehitaman di atasnya. Kesimpulan: Diagnosis KSB ditegakkan berdasarkan anamnesis, pemeriksaan fisik, pemeriksaan dermoskopi dan histopatologi dengan terapi standar bedah eksisi elips.

nterferon gamma (IFN-γ) merupakan mediator inflamasi yang penting pada penyakit psoriasis vulgaris. Berdasarkan penelitian sebelumnya didapatkan hubungan antara peningkatan kadar IFN-γ dengan derajat keparahan psoriasis vulgaris. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar serum IFN-γ dengan derajat keparahan psoriasis vulgaris. Metode penelitian adalah cross-sectional dengan sampel pasien psoriasis vulgaris dan bukan psoriasis vulgaris, berumur 16-65 tahun, yang berkunjung ke Poliklinik Kulit dan Kelamin RSUP Sanglah pada periode Oktober sampai Desember 2017, berdasarkan kriteria inklusi dan eksklusi. Penelitian ini melibatkan 70 orang sampel yang terdiri atas 42 orang pasien psoriasis dan 28 orang bukan psoriasis sebagai pembanding. Hasil penelitian didapatkan pasien psoriasis terbanyak berjenis kelamin laki-laki sebanyak 29 orang (69 %), dengan rerata umur 45,9 ± 11,1 tahun. Kadar rerata serum IFN-γ pada pasien psoriasis didapatkan 2,95 ± 2,29 ng/mL (IK 95%: 2,29–3,80ng/mL) lebih tinggi dibandingkan dengan bukan psoriasis 2,14 ± 1,78 ng/mL (IK 95%:1,74– 2,63ng/mL) dengan perbedaan rerata kadar serum IFN-γ pada kedua kelompok adalah 0,81 ng/mL dan bermakna secara statistik (p<0,001). P

Background: Heavy smokers have four times more facial wrinkles than non-smokers. Superoxide dismutase (SOD) levels are an indicator of premature aging in blood and tissues. The premature aging process can take place more quickly at a relatively younger age. The purpose of this study was to determine smoking and low levels of superoxide dismutase (SOD) as risk factors for premature aging in women aged 20-35 years. Method: Using a case-control study, this study determined smoking and low levels of superoxide dismutase (SOD) as risk factors for premature aging in women aged 20-35. Subjective clinical observation of wrinkles with the smoker’s face criteria (Daniel 1971) and objective use A-One-Facial Analyzer tool. Analyze using SPSS 26. Result: The smoking increased the risk of premature aging by 16 times (OR 16; 95% CI= 4,2-60,7); p<0,001) and passive smoker 36 times (OR 36; IK95% 7,6-168,9; p<0,001). Low SOD levels (<2.93 U/ml) increased the risk of premature aging by 9.7 times (OR 9.7;95%CI =3.2-29.1); p <0.001) and levels of superoxide dismutase (SOD) of smokers were lower than non-smokers with a median (IQR) [min-max] of smokers 1,5 (1,6) [0,4-9,7]U/ml while non-smokers were 7,5 (6,3) [0,1-14,2]U/ml and p<0.001. The results of the multivariate analysis showed that smoking and low SOD as risk factors for premature aging in women aged 20-35 years with smoking (AOR 18; 95%CI=5,5-66,8; p<0,001) and low SOD (AOR 10,2; 95%CI=1,5-67,1; p<0,001). Conclusion: That smoking and low levels of superoxide dismutase (SOD) as risk factors for premature aging in women aged 20-35 years.

Background: Lipschutz ulcer, also known as vulvae acutum ulcer, is an acute ulcer in the vulva. The aetiology and pathogenesis of Lipschutz ulcer are unclear, but it is known to be associated with infectious diseases such as Mycoplasma infection, paratyphoid fever, influenza A, and most infections with Epstein-Barr virus (EBV). This ulcer appears in adolescent females aged 14–20 years old, with 70% of cases occurring in virgin women. Purpose: To review the causes of non-Sexually Transmitted Diseases (STD) ulcers, so clinicians can establish an accurate diagnosis and rational therapy; therefore, minimizing the psychological impact on the patient due to possible misdiagnosis of STD-induced ulcer. Case: A painful wound in the genital area of a 20-year-old virgin woman. She was diagnosed with Lipshutz ulcer and vulvovaginal candidiasis based on the anamnesis, physical examination, and laboratory examination obtained from vaginal discharge using potassium hydroxide, Gram staining, and blood test to exclude genital ulcer caused by the sexually transmitted agent. A blood test was taken, including the serological tests for syphilis and genital herpes. Tests for EBV were also performed. The patient was treated only with single-dose fluconazole 150 mg orally and saline compress on the ulcer. Genital ulcer and vaginal discharge improved one week after treatment. Discussion:  Lipshutz ulcer management is symptomatic, usually self-limiting, and disappears spontaneously within 1–2 weeks without recurrences. It can also occur as a single lesion with possible coinfection of other agents, for example, candidiasis, which in this case, requires treatment of comorbidities. Hygiene factors play an essential role in preventing occurrence of the secondary infection and further development of the disease. Conclusion: The diagnosis of Lipshutz ulcer is mainly based on clinical manifestation after excluding several possible ulcers that can affect the genital area, including sexually transmitted infections.