RÉSUMÉ À Fès-Boulemane (Maroc), il n'y a pas de registre du cancer et donc pas d'informations sur l'incidence et les caractéristiques du cancer dans cette région. Dans la présente étude rétrospective, nous avons examiné le profil épidémiologique et anatomopathologique de 5532 cas de cancer colligés au Service d'Anatomie pathologique du CHU Hassan II de Fès de 2004 à 2010. L'âge moyen des patients est de 53,5 ans avec une prédominance masculine (52 %). Les cancers les plus fréquents sont les cancers digestifs et cutanés. Les cancers digestifs se singularisent par la prédominance des cancers du côlon-rectum et de l'estomac. Les cancers de la vessie et du côlon-rectum représentent les premiers cancers chez l'homme, comptant respectivement pour 9 % et 8 % des cas. Chez la femme prédominent les cancers du sein (62 %) et du col utérin (22,6 %). La mise en place d'un registre des cancers dans notre région est recommandée comme première étape de la lutte anticancéreuse. ABSTRACT In Fez-Boulemane, Morocco, there is no cancer registry so there is a lack of information about the incidence and characteristics of cancer in the region. In this retrospective study we examined the epidemiological and pathological features of 5532 cases of cancer collected from the Department of Pathology in Hassan II University Hospital of Fes from 2004 to 2010. The mean age of the patients was 53.5 years and 52% were male. Digestive cancers and skin cancers were the most common. Digestive cancers were predominantly colorectal and stomach. Cancers of the urinary bladder and colorectal cancers were the leading cancers in men accounting respectively for 9% and 8% of all male cancers. In women, cancers of the breast (62%) and uterine cervix (22.6%) predominated. As a first step in cancer control in our area, establishment of a regional cancer registry is recommended.

IntroductionA granular cell tumor involving the breast parenchyma was first described by Abrikossoff in 1931. Localization of this lesion to the breast is very rare, accounting for between 5% and 15% of all granular cell tumor cases. We present this case because of the rarity of this tumor. It is frequently confused with breast carcinoma on clinical and radiological examination, and its diagnosis can therefore be challenging for clinicians, radiologists and pathologists.Case presentationWe report the case of a 32-year-old Moroccan woman who presented with a palpable mass in her right breast. Mammography and ultrasound examination revealed a heterogeneous, irregular and poorly limited mass, located at the union of the outer quadrants of her right breast. The mass was in contact with her latissimus dorsi and suspicious for malignancy. A histological examination combined with immunohistochemical study revealed it to be a granular cell tumor.ConclusionAlthough a granular cell tumor of the breast is a rare breast neoplasm, it should be considered in the differential diagnosis of benign and malignant lesions. Pathologists should bear in mind a granular cell tumor when examining material containing cells with abundant granular cytoplasm to avoid misdiagnosing breast carcinoma, which could lead to unnecessary surgery.

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Introduction: Signet ring cell carcinoma is a rare tumor that generally originates in the gastrointestinal tract. Signet-ring cell carcinoma of the ampulla of Vater is extremely uncommon and a very rare clinical entity, which is infrequently reported in medical literature and only 31 cases have been mentioned. Most tumors affecting Vater's Ampulla are adenocarcinomas and other histological variants are less frequent. It mainly occurs in elderly patients. Case Presentation: We report a case of signet ring cell carcinoma of Vater's Ampulla. The tumour had infiltrated the duodenal, but local lymph nodes were clear (T3N0M0). Duodenopancreatectomy with pylorus preservation is the treatment of choice. Conclusions: Etiology and survival are not well-defined in the literature due to the extreme rarity of this disease.