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Modern genetics uses a number of methods that are its tools in understanding the essence of human hereditary pathology. Genetic methods are usually used together. Understanding the possibilities of methods for studying human genetics is the key to successful diagnosis of hereditary diseases. The lecture presents methods for studying modern genetics. It is shown that clinical genetics operates with a number of methods that allow successfully solving the tasks assigned to it. The methods of modern genetics include: genealogical, clinical, cytogenetic, molecular cytogenetic, molecular genetic, population, twin, dermatoglyphic, bioinformatic, biochemical, paraclinical, bioengineering methods and modeling method. All methods are of practical importance and help to make a diagnosis and predict the development of the disease. Methods in genetics are used in diagnostic schemes when making a diagnosis of a hereditary disease. In clinical practice, as a rule, methods with the lowest cost are used first, and then more accurate, modern, but also expensive methods are resorted to. This allows you to establish the diagnosis of even the rarest hereditary disease.

The data of near-field transient electromagnetic sounding, which are widely used for the purposes of oil and gas exploration within the Nepa-Botuoba anteclise, are typically interpreted in terms of quasi-horizontally-layered models of media. The purpose of this study is to develop an approach to the inversion of transient electromagnetic sounding curves obtained via high-density 3D observation networks. The study was based on mathematical modeling, whose results allowed to estimate the lateral spatial parameters of a non-stationary electromagnetic field as well as to understand the differences between the results of one-dimensional inversion of the transient electromagnetic sounding data and the true parameters of the target horizon. As a result, the characteristic of the electromagnetic field described by an exponential function and used in the lateral-constraint inversion of high-density electromagnetic sounding was obtained. The proposed approach was tested on the practical data within the site under investigation located on the slope of the Nepa-Botuobа anteclise. It is shown that the use of spatial discrepancy under TEM sounding data inversion makes it possible to obtain geoelectric models characterized by lateral consistency of section geoelectric parameters. The application of the spatial stacking-based approach in the inversion process allows to increase the solution stability of the inverse problem of the near-field TEM sounding data.

The article deals with the first results of integrated geohazard monitoring conducted by the Institute of the Earth's Crust SB RAS on the territory of Pribaikalye in 2020. The pilot network consists of three sites: "Buguldeika", "Priolkhonye" and "Listvyanka", each of which is equipped with high-precision digital devices including a broadband seismic station, a GPS receiver, deformometers, a sensor of soil radon emanations, and an observation station for the Earth's electromagnetic environment. This equipment is designed to acquire quantitative information on rock deformation, recent movements and geophysical field variations for solving theoretical and applied problems of geodynamics and seismology, including development of earthquake prediction methods. In the vicinity of the sites, there have been made the hydroisotopic measurements as well as observations over the character of some of exogenous processes. Based on the comprehensive analysis of the seismological, tectonic, deformation and emanation data, acquired also through monitoring, there has been obtained the preliminary characteristics of the Kudarinsky earthquake (December 9, 2020, M W =5.6) that was followed by intensity 5 aftershocks in large cities of the southeastern East Siberia -Irkutsk, Shelekhov, Angarsk, Usolye-Sibirskoe and others. It has been found that the seismic event manifested itself almost in all the fields monitored. This implies the network efficiency for a purposeful study of the precursors of large earthquakes which can initiate the development of other hazardous geological processes in Pribaikalye. The deformation monitoring data show some general patterns of earthquake source evolution which corresponds to the fundamental principles of physical mesomechanics. This opens the prospects for diagnostics of the final phase of earthquake generation in the context of meta-instable state of deformation process and rock mass disintegration.