Цель. Изучить изменения системы гемостаза во время хирургической операции и в раннем послеоперационном периоде у пациентов с плановой хирургической патологией. Материал и методы. В исследование включено 183 пациента, которым выполнены эндопротезирование тазобедренного сустава, остеосинтез бедренной кости, операции на пищеварительном тракте, гепатопанкреатоденальной зоне, мочевыделительной системе, реваскуляризирующие операции на аорте и магистральных артериях. У пациентов на всех этапах оперативного вмешательства определяли уровень показателей свертывающей, фибринолитической и антиагрегантной систем крови. Результаты. Во время оперативного вмешательства и в раннем послеоперационном периоде инициируется развитие гиперкоагуляционного синдрома с максимумом его развития к 3 часам после операции. Составляющей основой последнего является повышенное содержание тромбин-фибриновой фракции. Формирование гиперкоагуляционного синдрома происходит при активации агрегатной системы на фоне депрессии фибринолитического звена свертывающей системы. Послеоперационный венозный тромбоз диагностирован в 45 (24,59%) наблюдениях: в системе глубоких вен-у 37 (82,22%), а варикотромбофлебит-у 8 (17,78%) пациентов. Из них в первые 72 часа после операции венозный тромбоз диагностирован у 15 (33,33%) пациентов. Заключение. Установлено формирование гиперкоагуляционного синдрома непосредственно во время оперативного вмешательства и в раннем послеоперационном периоде. Процесс в основном развивается за счет накопления тромбин-фибриновой фракции на фоне низкой активности фибринолитической системы при усиленной агрегационной способности тромбоцитов. Гиперкоагуляционный синдром создает условия для формирования тромботического процесса. Одним из основных слагающих компонентво гиперкоагуляционного синдрома является тромбин-фибриновый фактор, преобладающее влияние на который проявляет нефракционированный гепарин (НФГ). Тромбопрофилактику необходимо начинать по окончании оперативного вмешательства НФГ и продолжать в первые 72 часа послеоперационного периода, на фоне введения низкомолекулярного гепарина согласно отраслевым стандартам, которые оказывают преобладающее влияние на Ха фактор. Ключевые слова: гиперкоагуляция, тромбоз глубоких вен, венозный тромбоэмболизм, тромбопрофилактика, антикоагуляция Objectives. To study the changes in the hemostatic system during surgery and in the early incisional period in patients with the planned surgical pathology. Methods. The study included patients (n=183) who underwent arthroplasty of the hip joint, osteosynthesis of the femur, operations on the digestive tract, hepatopancreatoduodenal region, urinary system, revascularization surgeries on aorta and main arteries. The levels of indicators of coagulative, fibrinolytic and antiplatelet blood systems were being determined at all stages of surgery. Results. The development of hypercoagulation syndrome, with a maximum of its development by 3 hours after the operation was occurred in the intraoperative stage of the surgery and within the early incisional period. The b...
Objective. To propose the prognostication method for the complications occurrence after operative interventions, basing on application of multiparametric neuro-web clasterisation with subsequent elaboration of scale for their development risk stratification. Materials and methods. The indices of examination were analyzed in 411 patients, suffering obliterating atherosclerosis of main arteries of the lower extremities. The neuro-web clasterization, using a software raising NeuroXL Classifier, was conducted for more deep analysis of concomitant changes in the indices investigated for the risk prognostication optimization of the morbidity development in postoperative period. Results. The scale of the risk stratification for development of postoperative complications after interventions on the main arteries of the lower extremities proposed, takes into account multifactor character of clinic-anamnestic and laboratory-instrumental investigations. Taking into account the concomitant factors presence, which characterize the organs and systems state, they impact the choice of method of reconstructive operative intervention. Conclusion. Basing on data of the neuro-web clasterization, it is possible to prognosticate the complcations after operative intervention on the main arteries of the lower extremities. There were delineated four levels of the complications development risk in postoperative period: very high – 31-40 points, high – 21-30 points, moderate – 11-20 points, and low – 1-10 points.
Introduction. Number of patients with obliterating lesions of the aorta and main arteries of the lower extermities has been steadily increasing every year. When choosing the scope of surgical treatment all the features of the multilevel stenotic-occlusive process of the infrainguinal arterial bed should be taken into account. Purpose. To improve the results of revascularization of the infrainguinal arterial bed by applying surgical intervention on profound femoral artery and endovascular methods to restore permeability of the outflow arteries. Materials and methods. The work is based on the results of examination and surgical treatment of 264 patients with stenotic-occlusive process of the infrainguinal arterial bed. There were four groups of patients. The basis of revascularization interventions on the infranguinal artery was shunt surgery. Bypass surgery was performed using a reverse autovein. The combined shunt was used for localization of the distal anastomosis at the level of the popliteal, shin arteries, tibioperinel trunk. Results. In atherosclerotic stenotic-occlusive lesions of the infrainguinal arterial bed of the lower extremity, the volume of surgical treatment depends on the level of the occlusive process, the functional state of the PFA and the blood flow pathways. And the method of surgical intervention in shunt interventions is determined by the type of distal lesion and the level of imposition of distal and proximal anastomoses. Conclusion. The use of endovascular methods of revascularization and reconstructive interventions on PFA in combination with femoral-distal shunt operations contributes to good and satisfactory results of surgical treatment of stenotic-occlusive processes of the infrainguinal arterial bed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.