Background: Delirium often occurs to the elderly, which is associated with inflammation, malnutrition and low activities of daily living (ADL). The reduced ADL is associated with poor outcomes and death. ADL is affected by malnutrition and inflammation. Albumin is a marker for malnutrition and inflammation, while the neutrophil-lymphocyte ratio (NLR) is a marker for inflammation. This study aims to determine the relationship between albumin serum levels and NLR to ADL in elderly delirium patients in Sanglah Hospital Denpasar.Methods: A cross-sectional correlative study among elderly delirium patients were conducted at Sanglah Hospital Denpasar from January to July 2018. The variables studied were albumin levels, NLR and ADL scores. Data analysis using SPSS version 23 with Pearson or Spearman correlation tests to determine the relationship between the variables examined.Results: Total of 73 patients were sampled. The average albumin levels were 3.35 gram/dL, the median NLR was 8.17 and the median ADL scores were 3. There was no significant relationship between albumin and ADL in elderly delirium patients (p=0.35, r=0.10), but a significant correlation was obtained between NLR and ADL scores (p=0.04, r=-0.24).Conclusion: Albumin did not significantly affect ADL. NLR was negatively correlated with ADL. The higher the NLR, the lower the ADL of elderly delirium patients.Â
Stevens-Johnson syndrome (SJS) is a cutaneous immunity reaction involving the skin and mucosa and is an emergency condition that can be fatal. The incidence of this disease is relatively rare in the range of 1-2 per 1.000.000 population. The pathogenesis of SJS involves the immune system response of antigenic drug to body tissues but it still cannot be fully explained to date. We reported a woman, 35 years old with systemic lupus erythematosus (SLE) who had been on steroid therapy and in the course of treatment developed into SJS after administration of anti-epileptic drug. Steroids have anti-inflammatory effects mainly due to decreased syntheses or suppression of inflammatory mediators. SJS still can develop in patient with SLE who had been on steroid therapy. Giving steroid that indicated for the treatment of a disease including SLE, cannot prevent the occurrence of an allergic event including SJS. The presence of steroid can extend the duration of starting the drug with the occurrence of SJS and reduce the severity of the disease. Steroid still have a role in treatment that can be used both in SJS and SLE.
Background: Good quality of life is the expected goal of long-term treatment of HIV/AIDS patients. This quality of life can be influenced due to stigma of this disease. This stigma can affect psychic, loss of trust, work and patient social interaction. Objective: Determine the relationship between stigma and duration of HIV/AIDS therapy on the quality of life patients with HIV/AIDS at Sanglah General Hospital Denpasar. Methods: This was a cross sectional study with sampling of patients visiting the Sanglah General Hospital Denpasar VCT Clinic. The variable was assessed using Berger HIV Stigma Scale (HSS) and World Health Organization-Quality of Live HIV-BREF (WHOQOLHIV-BREF). Both of these instruments had been validated into Indonesian version. Data analysis using Pearson correlation to determine the correlation between stigma and duration of HIV/AIDS therapy on quality of life patients with HIV/AIDS. Results: A total of 76 patients were sampled with an average length of treatment for 53,66 months. There was a significant relationship between stigma on the quality of life patients (p=0,04, r=-0,229), while the duration of treatment did not affect the quality of life patients (p=0,61, r=0,059). Stigma correlates with the quality of life based on WHOQOLHIV-BREF, especially from the psychological aspect (p=0,007, r=-0,306) and social aspects (p=0,04, r=-0,232). Conclusion: Stigma was negatively correlated with the quality of life patients with HIV/AIDS. The higher the stigma experienced by patients, the lower the quality of life of these patients. The duration of patients underwent therapy did not relate to the quality of life patients with HIV/AIDS.
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