with antibiotic leftovers or by acquiring antibiotics directly in the pharmacy without a prescription), are behaviours directly related with this misuse, revealing the necessity of interventions directed to health professionals. The aim of this study is to improve the consumption of antibiotics through an educational intervention directed to community pharmacists and primary care physicians. Material and Methods: A cluster randomized trial in the region center of Portugal. Of the 8 clusters, 4 clusters received an educational intervention and the other four clusters did not received any intervention and were included in the control group. Educational intervention consisted of group sessions with physicians and group sessions with pharmacists. In the sessions groups it was presented information about the problem of microbial resistances and each sessions was focused in the identified attitudes that influence the behaviour of physician during antibiotic prescription or the behaviour of pharmacist during the dispensation of antibiotics in pharmacies. At the end of each group session, were distributed flyers and poster about the importance of the adequate use of antibiotics to be divulgated to the patients. The data of antibiotics consumption was compared between the intervention group and the control group. Results: The intervention was well received for the pharmacists and for the physicians included in the study. Comparing the consumption of antibiotics between the two groups, it was observed a decrease in the total consumption of antibiotics in the intervention group during 12 months of the follow-up period after the intervention was made. Conclusions: It was possible decrease the consumption of antibiotics through an educational intervention directed to community pharmacists and primary care physicians.

No abstract

The form factor of mobile devices and their associated thermal dissipation characteristics present practical limits to SoC (and specifically CPU) power consumption. Multiple maximum temperature constraints interact with the thermal "time constant" of package and product to limit allowable die temperature. This can constrain maximum CPU frequency in real use cases. The co-design of product and process technology is required to maximize thermally constrained performance. Technology features, device Ieff/Ioff setpoints, and circuit design styles are all levers to optimize thermally constrained performance. A methodology for early prediction of product sensitivities to these levers is required to enable their definition sufficiently early in the development cycle of the technology node.