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Using a model of "bony tissue tunnel defect" produced by the removal of a mandibular incisor in rats, it was found that closing the defect with a bioprosthesis prevented the washing out of osteogenic bone marrow precursor cells, which serve as a substrate for reparative osteogenesis, from the mandibular spongy bone. The reparative process was strongly stimulated if the bioprosthesis contained estrone, in this case, the time required for the tooth socket to be filled with osteogenic tissue was shortened by half. When no bone marrow elements were present in the socket, it was Idled with fibrotic connective tissue, the number of bone marrow elements in spongy bone cavities was small, and the mandibular osteogenic tissue underwent atrophy.

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The choice of stromal differentiation by polypotent stem cells was studied by morphological and chemiluminescent methods. The differentiation pathway is selected on day 7 after heterotopic bone marrow transplantation and injection of estrone. The imbalance in plasma oxidant homeostasis in mice on day 7 after estrone injection is associated with drastic intensification of free-radical oxidation and blockade of antioxidant activity.