lower, than in the ] ng/ml (p>0.05); ] pg/ml and 8.5 [3.3-46.0] pg/ml respectively (p<0.05); ] pg/ml and 26.5 [11.2-79.2] pg/ml respectively (p<0.001). In women with obesity, 45 (83.3%) children were mature, 9 (16.7%)premature. Mean gestational age of mature newborns -38.4±0.2 weeks, premature -33.8±0.6 weeks (p<0.001). Body weight of mature children was 3,680.0 [2,958.0-4,040.0] grams, premature -2,000.0 [1525-2065] grams (p<0.001). Median level of 25(OH)D in mature newborns -8.8 [4.0-14.6] ng/ml, in premature -4.0 [3.9-4.5] ng/ml (p<0.01); IL-1b -20.4 [11.2-34.0] pg/ml and 38.1 [32.0-93.8] pg/ml respectively (p<0.01); IL-6 -84.6 [56.6-166.8] pg/ml, versus 64.6 [32.0-161.6] pg/ml (p>0.05). In mothers with obesity, 14 (25.9%) newborns had intrauterine infection, calcidiol level was 6.4 [4.0-13.4] ng/ml; IL-1b -17.4 [9.2-23.9] pg/ml; IL -6 -92.8 [45.6-190.6] pg/ml, which is 3.5 times higher, than in the CG (p<0.01).Conclusions The vast majority of newborns, born by mothers with obesity, had hypovitaminosis D, these children also had conclusively high level of IL-1b and IL-6. In newborns with intrauterine infection, IL-1b and IL-6 content reaches the highest level versus the CG.

Background and Aims Congenital heart defects (CHD) are the most common group of congenital malformation. With advanced testing-such as microarray and Next Generation Sequencing (NGS)-applied into routine clinical practice, more genetic anomalies may be detected in infants with CHDs. Aims and Objectives The study was aimed to investigate the association between the congenital heart defects and genetic anomalies. Methods A retrospective observational study included all the infants with a recoded new diagnosis of born CHD between 01/ 01/2017 and 31/12/2018, from a single tertiary neonatal intensive care unit. The data were recorded from the electronic patient records. For analytic purposes, CHDs cases were divided into 4 categories: critical, serious, significant or non-significant types. Results 229 infants were identified, of which 8 were excluded due either to a lack of follow up or death from non-cardiac causes, which made classification impossible. 93% of infants with critical CHD, and 85% of those with serious CHD, had relevant genetic testing, of which 31% and 41% had positive diagnoses, respectively. Significantly more infants with critical or serious CHD underwent relevant genetic testing than the infants with significant (50%) or nonsignificant (12%) CHD (p-value <0.01). Of the 24 infants with critical, serious or significant CHD diagnosed with a CHD related genetic anomaly: 8 were diagnosed with Trisomy 21; 3 with Noonan's syndrome; 1 with DiGeorge and the remainder with various microdeletions, microdeletions and single nucleotide variants. Conclusions In our cohort, around one-third of the infants with critical and serious heart conditions had underlying genetic defects. The infants with critical and serious heart condition needing surgery or intervention within one year after birth are often tested for the underlying genetic defect. The uptake of genetic testing was far less in infants with significant or minor CHDs.

prednisolone) and propranolol are commonly prescribed and lesions unresponsive (15% cases) have been treated with antiangiogenic agents such as IFN-alpha, sirolimus, vincristine and cyclophosphamide.Invasive measures like hepatic artery ligation or embolization may be tried in complicated cases. Surgical therapy is recommended for uni-lobe lesions, masses with low potential for regression or in suspected malignancy.In summary, this case always had a poor prognosis as it was multifocal, had intra-hepatic shunting and was complicated by CCF and haemorrhage. Unfortunately TAE wasn't successful on this occasion but sub-speciality involvement was greatly appreciated.

dengue infection was seen in 95% and 5% respectively (table 1). Though among those with titres over 80 Panbio units the frequency of severe dengue was slightly higher (14.3% vs 4.3%), there was no significant association between the Ns1antigen titres and clinical severity of dengue. p value 0.82. Abstract G158(P)Table 1 Ns1Ag titre Dengue without Warning signs Dengue with Warning Signs Severe Dengue Total G161(P) ABSTRACT WITHDRAWN Abstracts Arch Dis Child 2019;104(Suppl 2):A1-A279 A65