Global Retinoblastoma Study Group IMPORTANCE Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale.OBJECTIVES To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. DESIGN, SETTING, AND PARTICIPANTSA total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. MAIN OUTCOMES AND MEASURESAge at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. RESULTSThe cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4%) were female. Most patients (n = 3685 [84.7%]) were from low-and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 [62.8%]), followed by strabismus (n = 429 [10.2%]) and proptosis (n = 309 [7.4%]). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 [95% CI,, and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 [95% CI,). CONCLUSIONS AND RELEVANCEThis study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs.

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Retinopathy of prematurity (ROP) is a major cause of visual impairment in premature infants that are actually very likely to be avoided. The risk factors that most influence on the incidence of ROP is oxygen. This research was conducted to determine the effect of duration, fraction and method of applying oxygen on the incidence of ROP in premature infants at Sanglah Hospital. This research is an analytic observational with case control study design, where the study was divided into two groups, namely the case group and the control group. Data were analyzed using bivariate using chi-square test and analyzed by multivariate logistic regression. Statistical significance was assessed using IK 95% and the P value at the limit of α = 0.05. After multivariate analysis was conducted with logistic regression to variable oxygen usage duration> 7 days, the oxygen fraction> 40% and oxygen use with CPAP or mechanical ventilation, it was found that the most influential variable is the application of oxygen fraction> 40% where the value adjusted RO 40.8 with a range of 2.8 to 594.8 IK 95%,

Background: Retinopathy of prematurity (ROP) is the major cause of blindness in neonates worldwide. The incidence of preterm birth in live-born infants in Cipto Mangunkusumo Hospital in 2007 was 20.22%, and 71% of preterm babies have repaired retinopathy of prematurity.Aim: This literature review aims to determine the effects of inflammatory factors on the formation of retinopathy of prematurity, such as interleukin-6, interleukin-1, COX-2 and Tumor Necrosis Factor-Alpha (TNF-α).Conclusion: Hopefully, the information would help construct a more comprehensive approach toward patients with ROP.Â

Background: Traumatic cataract is a cataract that occurs as a result of injury to the eye which can be a sharp or blunt trauma that is seen after a few days or several years. This traumatic cataract can occur acute, subacute, or residual symptoms of eye trauma, often due to an injury caused by a foreign object that hits the lens or blunt trauma to the eyeball. The purpose of this study was to determine the profile of traumatic cataract sufferers which included the characteristics of age, sex, and occupation at the Sanglah Central Hospital in Denpasar, Bali.Method: This study was descriptive with a cross-sectional study design. This research is retrospective and uses secondary data obtained from medical records.Result: Results of the study with cross sectional descriptive test showed that 58.3% of cases occurred in the male sex and 41.7% in women. The age ranges from 5 years to 69 years with an average sample age of 38.25 + 2.6 years. The occupations that dominated were students and farmers with a percentage of 25% each, followed by housewives with a percentage of 16.7%.Conclusion: In this study traumatic cataracts were found to be more common in male rice, with an average age of 38 years and occupations as students and farmers. Based on clinical characteristics, the eyes most affected by traumatic cataracts are the left eye and the most common cause is blunt trauma.  Latar Belakang: Katarak traumatika merupakan katarak yang terjadi sebagai akibat cedera pada mata yang dapat merupakan trauma tajam ataupun tumpul yang terlihat sesudah beberapa hari ataupun beberapa tahun. Katarak traumatika ini dapat terjadi akut, subakut, atau pun gejala sisa dari trauma mata, sering terjadi karena adanya cedera yang disebabkan oleh benda asing yang mengenai lensa atau trauma tumpul pada bola mata. Tujuan penelitian ini adalah untuk mengetahui profil penderita katarak traumatika yang meliputi karakteristik usia, jenis kelamin, dan pekerjaan di Rumah Sakit Umum Pusat Sanglah Kota Denpasar, Bali.Metode: Penelitian ini adalah deskriptif dengan rancangan penelitian potong lintang (cross-sectional). Penelitian ini bersifat retrospektif  dan menggunakan data sekunder yang diperoleh dari rekam medis.Hasil: Hasil penelitian dengan uji deskriptif cross sectional menunjukkan bahwa 58,3% kasus terjadi pada jenis kelamin laki-laki dan 41,7% pada perempuan. Usia berkisar dari 5 tahun hingga 69 tahun dengan usia sampel rata-rata 38,25 + 2,6 tahun. Pekerjaan yang mendominasi adalah siswa dan petani dengan persentase masing-masing 25%, diikuti oleh ibu rumah tangga dengan persentase 16,7%.Simpulan: Pada studi ini ditemukan katarak traumatika lebih sering terjadi padi laki-laki, dengan rata-rata usia 38 tahun dan pekerjaan sebagai pelajar dan petani. Berdasarkan karakteristik klinis, mata yang paling banyak terkena katarak traumatika adalah mata kiri dan penyebab tersering adalah trauma tumpul.