The age-dependent alterations of phagocytosis and age-dependent cell change (ADCC) activity through Fey receptors of human monocyte monolayers using anti-D human IgG-coated ⁵¹Cr-labeled human red blood cells were determined. 40 healthy aged subjects of both sexes (age: 60–85 years) and 20 healthy young people of both sexes (age: 18–25 years) were studied. The phagocytosis increased significantly with aging in both sexes, whereas a decrease in ADCC activity was found.

Phenacetin should be banned. Our study results support the need for longitudinal cohort and case-control studies in Hungary.

The body composition of 40 healthy elderly and 20 healthy young subjects was determined and compared. It was found that the age-related changes were more marked in females than in males. Total body water was decreased as a consequence of diminished lean body mass. Extracellular fluid volume remained unchanged, while plasma volume increased. Thus, the liquid components of lean body mass were redistributed between the intracellular and extracellular spaces. The elimination kinetics of isotopes were not significantly different between young and aged subjects, except the elimination of radiosulfate.

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