Background: Nutritional status has been shown to predict post-surgical recovery and clinical outcomes in orthopedic patients. This study evaluated the effects of an oral nutrition supplement (ONS) in patients undergoing hip fracture surgery. Materials and Methods: In a multicenter, prospective, randomized study (ClincialTrials.gov, registration number NCT01011608), malnourished patients (n=127) who had surgery within 14

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We carried out a comparative experimental and clinical study of the efficiency of the combination of dermal matrix with autologous and allogenic cells for creation of an optimal biological wound coating. Experiments on outbred mice have demonstrated that the use of dermal matrix in combination with allogeneic or autologous cells shortens the inflammation phase and accelerated maturation of the granulation tissue. Clinical application of biological wound dressing based on dermal matrix in combination with autologous or allogeneic mesenchymal multipotent stromal cells prevented septic complications and shortened the time of preparing extensive traumatic wounds with skin defect to autodermoplasty.

New effective method of active immunoprophylaxis of Bacillus Pynocyaneous in victims with open long bones fractures was elaborated. Anatoxin of Bacillus Pynocyaneous (15-30 mkg of protein/day) was injected into medullar canal of injured limb for 3-5 days after trauma. Injection of anatoxin was performed through microirrigator that was placed at the time of first osteosynthesis operation. Application of that procedure activated all components of immunity at early stages (by 7 day after injury) resulting in subsequent increase of immune response. Advantages of the given method in comparison with standard scheme of active immunoprophylaxis were confirmed by immunologic study data as well as by favorable clinical outcome of wound process.