Two field experiments were conducted during 2010/2011 and 2011/2012 seasons at Shandaweel Agriculture Research Station, Sohag Governorate, Egypt, to study the effect of six sowing methods (Afir broadcast (AB), Afir broadcast on raised beds at 50 cm width (ABB-50cm), Afir broadcast on raised beds at 75 cm width (ABB-75cm), Afir drill at 15 cm apart rows (AD), Afir drill on raised beds at 50 cm width (ADB-50cm) and Afir drill on raised beds at 75 cm width (ADB-75cm), and five weed control treatments (Turonex at 1.0 l/fed, Ecopart at 250 cm 3 /fed + Illoxan at 1.0 l/fed., Ecopart + Topik at 140 g/fed, hand weeding twice and unweeded control) on weed growth, yield and yield components of wheat cultivar Giza 168. Split plot design was used. The results indicated that the sowing methods of Afir drill and broadcast on raised beds at 75 cm widths were the best methods in weed control and gave the lowest values in the dry weight of grassy, broad-leaved weeds and total weeds (g/m 2 ), followed by Afir drill and Afir broadcast on raised beds at 50 cm in both seasons, respectively. Sowing methods Afir drill and broadcast on raised beds at 75 cm widths gave the highest values for plant height, spike length, weight of the spike, the number of spikes m -2 , grain protein, straw (ton/fed) and grain yield (ardeb/ fed) in both seasons. Weed control treatments reduced significantly the dry weight of grassy, broad-leaved and total weeds compared with unweeded treatment in both seasons. Ecopart + Topik and hand weeding twice were the best in weed control of grassy, broad-leaved and total weeds and plant height, spike length, weight of the spike, the number of spikes/m -2 , grain protein %, 1000-grain weight, straw (ton/fed.) and grain yield (ard./ fed.) in both seasons compared with unweeded treatment. The interaction between sowing methods and weed control treatments was significant on all dry weight weeds and plant height in both seasons and spike weight in the second season only. Afir drill and broadcast on raised beds at 75 cm width with (Ecopart + Topik) or hand weeding twice gave the highest average of the numbers of spikes/ m 2 (443.3 and 332.2) and (488.7 and 437.3), 1000-grain weight (52.4 and 53.6 g) and (47.7 and 50.5 g) and grain yield (21.97 and 22.52) and (19.42 and 19.93 ard./fed.) in the average in both seasons for two sowing methods with two weed control treatments.There were no residues of herbicides (isoproturon 55% SC at a rate of 1.5 L/fed., pyraflufen-ethyl 2% SC at 250 cm 3 /fed. and clodinafop-propargyl 15% WP at 140 g/ fed. as post emergence herbicide on the tested wheat grain. However, detection residue for (diclofop-methyl 36% EC at 1 L/fed.) herbicide in wheat grain (0.09 ppm) was lower than the Maximum Residue Limits (MRL).Economic evaluation of the results indicated that the benefit/cost ratios for wheat yield/fed reached about 128.36 and 181.42%/fed with Ecopart + Topik with Afir drill on raised bed at 75 cm width in the first and the second seasons, respectively. While, unweeded treatment with Afir bro...