The continuous use of antibiotics for the treatment of bacterial infections has led to the increase in bacterial resistance to these antibiotics. Many bacteria, including Staphylococcus aureus are currently multi-drug resistant, which poses a great problem to the medical and pharmaceutical industry [1]. This research was conducted to investigate the antimicrobial properties of Syzygium aromaticum against the above-mentioned organism. The plant extracts were Hot water, Cold water, and Ethanol, and the susceptibility of the organism was tested using agar well diffusion and disk diffusion methods. The plant extracts showed antimicrobial activity on the isolate used i.e. Staphylococcus aureus. From the result, the minimum inhibitory concentration (MIC) was 0.24mg/ml, and the Minimum bactericidal concentration (MBC) was 3.91mg/ml. The Diameter Zone of Inhibition in (mm) against the plant concentration in (mg/ml) parameters were 500mg/ml and 250mg/ml. The values of the diameter zone of inhibition against the plant concentrations ranged from 16mm to 0mm while control ranged from 38mm to 10mm. The Phytochemical components determined in Cloves were Alkaloids, Saponin, Phenols, Tannins, Flavonoids, Steroids, Soluble Carbohydrate, Glycosides, and Terpenes.