Trisomy 13 (Sy Patau) is a clinically severe entity. 85% of the patients do not survive beyond one year, and most children die before completing six months of age. We report a female child, 30 day old, white, the third child of a non-consanguineous couple, who presented trisomy 13. The child was born at term, from a vaginal delivery, weighing 3200 g. The second day of life the development of respiratory distress translated ino KBC Kragujevac (release list no.29623). The initial clinical examination detected shisis primariy and secunday palate, ASD, stenosis rami AP, polidactily pedis dextri, microcornea and microftalmia. After 27 days of hospitalization in KBC Kragujevac, transferred to the Institute for mother and child New Belgrade, where he died after three days of receipt. During hospitalization blood samples were taken for determination of kariotip. Parents are advised that in case of subsequent pregnancies occur in the genetic counseling of the Institute for prenatal diagnosis. ApstraktTrizomija 13 (Patau sindrom) je ozbiljan klinički entitet. 85% pacijenata ne preživi duže od godinu dana, a većina umire pre nego što napuni šest meseci. Mi prikazujemo žensko novorođenče, uzrasta 30 dana, treće dete iz kontrolisane trudnoće, koje je imalo trizomiju 13. hromozoma. Dete je rođeno u terminu, vaginalnim putem, težine 3200 grama. Drugi dan života razvija respiratorni distres, pa je prevedeno u KBC Kragujevac. Na prvom kliničkom pregledu konstatovan je rascep primarnog i sekundarnog nepca, ASD, stenoza rami AP, polidaktilija desnog stopala, microcornea i microftalmia. Posle 27 dana hospitalizacije u KBC Kragujevac, prebačeno je u Institut za majku i dete Novi Beograd, gde je umrlo posle tri dana od dana prijema. Tokom hospitalizacije uzet je uzorak krvi za određivanje kariotipa. Roditeljima je savetovano da u slučaju ponovnih trudnoća dođu u genetičko savetovalište Instituta za prenatalnu dijagnostiku.Ključne reči: Patau syndrom, trizomija 13, hromozomopatija, novorođenče. UvodTrizomijа 13 (tаkođe poznаtа kao Pаtаu sindrom) je genetski poremećаj u kome osobа imа tri kopije genetskog mаterijаlа na hromosomu 13, umesto uobičаjenih dvа primerkа. Retko, ekstrа mаterijаl može biti vezаn zа drugi hromozom (trаnslokаcija) 1 .Sindrom je otkrio i opisao prvi put Klaus Patau (Klaus Patau) 1960. godine. Označava se 47 XX+13 ili 47 XY+13, u zavisnosti od pola 1 . Učestalost sindroma je oko 1:8000 -12000 zivorođenčadi. Specifičan etiološki faktora za nastanaka ovog sindroma nije nađen, ali postoji značajna povezanost sa starošću porodilja. U normalnim somatskim ćelijama čoveka broj hromozoma je 46, a u malom broju slučajeva, oko 5%, može se javiti i tzv. mozaicizam, pri kome postoje dve ćelijske linije: jedna sa normalnim brojem hromozoma, a druga sa trizomijom hromozoma 13. Obično su ovakve osobe sa blažim simptomima i lakšim oblikom bolesti 2,3 .Poremećaj se manifestuje multiplim anomalijama: rascep usne, vilice i nepca (heliognatopalatoshiza), mentalna retardacija, polidaktilija, pupčana i preponska kila, mala gla...

Incidenca karcinoma prostate na ponovljenim biopsijama kod pacijenata sa prethodno dijagnostikovanom visoko stepenom prostatičnom intraepitelnom neoplazijom i atipičnom sitno acinarnom proliferacijom na inicijalnoj biopsiji STRUČNI RAD / PROFESSIONAL ARTICLE The incidence of prostate carcinoma on repeated biopsy detected after an initial diagnosis of high grade prostatic intraepithelial neoplasia and atypical small acinar proliferation KORESPONDENCIJA / CORRESPONDENCE SAŽETAKCilj. Cilj istraživanja je bio da se uradi uporedna analiza VSPIN i ASAP nađenih na inicijalnoj biopsiji i AP dijagnostikovanog na ponovnoj biopsiji u odnosu na broj uzetih isečaka i broj zahvaćenih isečaka.Metode. Analizirano je 536 pacijenata sa urađenom iglenom biopsijom prostate. Primenjene su patohistološke metode istraživanja. Pacijenti odnosno iglene biopsije prostate svrstane su na osnovu broja uzetih uzoraka u tri grupe: I grupa 2-7 uzoraka (275 pacijenata), II grupa 8 -10 uzoraka (131) i III grupa 11-12 uzoraka (130) biopsije prostate. Takođe, prema broju iglenih uzoraka prostate zahvaćenih sa VSPIN i/ili ASAP svrstane su u dve grupe: monofokalno (zahvaćen jedan igleni uzorak prostate) i multifokalno (zahvaćeno 2-4 iglenih uzoraka prostate) zahvatanje.Rezultati. VSPIN i/ili ASAP su nađen u I grupi ukupno u 80 od 275 pacijenata(29,1%), u II u 50/131 pacijenata (38,2%) i u III grupi u 58/130 (44,6%). Od 201 pacijenata sa VSPIN i/ili ASAP rebiopsija je urađena u 55 (45 VSPIN, 7 ASAP i 3 VSPIN/ASAP). Od 55 pacijenata sa dijagnostikovanim VSPIN i ASAP na prvoj biopsiji, AP je u rebiopsiji nađen u 26 (47,3 %). AP je nađen u rebiopsiji u 18/45 (40,0%), sa VSPIN na inicijalnoj biopsiji, u 5/7 (71,4%) sa ASAP i u sva 3 (100%) sa istovremenim VSPIN/ASAP. Od 22 pacijenata monofokalnog zahvatanja VSPIN i/ili ASAP u 8 (36,4%) je u rebiopsiji bio nađen AP, a u 33 multifokalnog zahvatanja u rebiopsiji je u 18 (54,5%) nađen AP.Zaključak. Postoji statističko značajno veći rizik od nalaze AP na rebiopsiji, kod VSPIN i ASAP dijagnostikovanih na inicijalnoj biopsiji. Postoji statistički značajna korelacija u detekciji VSPIN, ASAP i AP u odnosu na broj uzetih isečaka, kao i statistički značajno veća učestalost kod multifokalnog zahvatnja u rebiopsiji.Ključne reči: neoplazije prostate; prostatična intraepitelijalna neoplazija; biopsija ABSTRACTObjective. The aim of our study was to determine the influence of the extent and involved needle biopsy sampling with HGPIN/ ASAP at initial biopsy, on the detection rate on the repeated biopsy.Methods. Our case series consists of 536 patients with initial needle biopsy of prostate. The patients were divided at three groups, according to the number of biopsy specimens: I group 2-7 biopsy specimens (275 patients), II group 8 -10 (131.) and III group 11-12 (130) biopsy specimens. We reviewed the repeat biopsy records of 55 patients in whom HG-PIN and/or ASAP had been detected on initial needle biopsy of the prostate (45 cases with HGPIN, 7 cases with ASAP and 3 cases with HGPIN/ASAP) According to the number of biop...

The aim of this paper is to present the incidence of placental abruption and placenta previa at GAO General Hospital N. Pazar like to stress the importance of bleeding in the second trimestreu pregnancy. A retrospective study was conducted at the department of gynecology and obstetrics, ZC Novi Pazar January 2008 December 2012th As the basis of the data, the history and the findings from the protocol konzervtaivno treated surgically and we pacijenata. Analizirali incidence of bleeding compared to the total number of births, maternal age, parity and gestation. During the period of 2008-2012, there were 186 abruption (1.72 %) and 34 placenta previa (0.31%). Within a given period, there were 10778 delivery of which 220 bleeding or 2.03 %. The incidence of placenta previa and ab.placente compared to 84.5% abruption and placenta previa 15.5%. The age of pregnant women who develop bleeding: the highest percentage of bleeding at the age of 26-31god (43.6%) than in the group of 19-25 years. 82.63 % and the lowest in the group under 18 (3.18) and above 35 years of age (11.3%). Maternal parity. primipara i 92 (41.88%), second child 49 (22.27 %) , third child i 46 (20.91%), fourth child 28 (12.72%). Gestational age at which it contacted the bleeding; 8 to 27 ng (3,645), 28-34 ng 30 (13.63 %) 0.35 to 37 ng 41 (18.64 %), and 37 ng 141 (64%). Method of delivery; caesarean 117 abruption (62%) vaginal delivery 69 (38%). Placenta previa; cesarean section 28 (82.3 %) and 6 vaginal (17.6 %). Any bleeding in the second half of pregnancy should be taken seriously. Prolong pregnancy as possible. You need to pay attention to risk factors: hypertension, gestational diabetes, smoking, previous cesarean section, and in this sense preventive effect on pregnant women.

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We are showing this event aimed to highlight the potential for gastroschisis at older mothers over 40 years and not only mothers younger population.The patient M. M, born in 1965, married in 41.years life diagnosed with uterine fibroids two. Three months after her marriage comes naturally to pregnancy. Sonographic findings: One fetus, pelvic presentation, amniotic fluid is optimal in the neck visibly thickened (accentuated nuchal traslucencija), BPD 25 mm, AC 84 mm, 14 mm FL, heart (-) NG / KL 15.2, NG / ultrasound 14.0, the placenta is embedded in the front wall of the uterus contraction. After careful observation in the area of insertion of the umbilical cord can be observed intestinal convolutions freely floating in the amniotic fluid. Grav.ml III IV.HBD ½-15 / 16.FMU. Anomalies foeti obs. Gastroshizis obs. Uterus myomatosus. Consultative decided to terminate the pregnancy GAO HC Novi Pazar. Ekstrahovana Bed, underwent explorative curettage and administered terapija.Fetus a whole with the umbilical cord and placenta sent to PH review. For three weeks the PH finding confirmed gastroschisis and miltipne anomalies. The paper describes the case female patient 41 years old, first pregnancy, in which the early second trimester of fetal gastroschisis diagnosed with absence of fetal heart rate. Pregnancy is consultative decision interrupted without complications.