Dysglycemia, in this survey defined as impaired glucose tolerance (IGT) or type 2 diabetes, is common in patients with coronary artery disease (CAD) and associated with an unfavorable prognosis. This European survey investigated dysglycemia screening and risk factor management of patients with CAD in relation to standards of European guidelines for cardiovascular subjects. RESEARCH DESIGN AND METHODS The European Society of Cardiology's European Observational Research Programme (ESC EORP) European Action on Secondary and Primary Prevention by Intervention to Reduce Events (EUROASPIRE) V (2016-2017) included 8,261 CAD patients, aged 18-80 years, from 27 countries. If the glycemic state was unknown, patients underwent an oral glucose tolerance test (OGTT) and measurement of glycated hemoglobin A 1c. Lifestyle, risk factors, and pharmacological management were investigated. RESULTS A total of 2,452 patients (29.7%) had known diabetes. OGTT was performed in 4,440 patients with unknown glycemic state, of whom 41.1% were dysglycemic. Without the OGTT, 30% of patients with type 2 diabetes and 70% of those with IGT would not have been detected. The presence of dysglycemia almost doubled from that selfreported to the true proportion after screening. Only approximately one-third of all coronary patients had completely normal glucose metabolism. Of patients with known diabetes, 31% had been advised to attend a diabetes clinic, and only 24% attended. Only 58% of dysglycemic patients were prescribed all cardioprotective drugs, and use of sodium-glucose cotransporter 2 inhibitors (3%) or glucagon-like peptide 1 receptor agonists (1%) was small. CONCLUSIONS Urgent action is required for both screening and management of patients with CAD and dysglycemia, in the expectation of a substantial reduction in risk of further cardiovascular events and in complications of diabetes, as well as longer life expectancy.

Acute stent thrombosis (AST) is associated with increased morbidity and mortality. The main aim of this study was to evaluate the prognostic value of the systemic immune-inflammation index (SII) and C-reactive protein (CRP) to albumin ratio (CAR) in predicting AST and high SYNTAX score in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). The criteria of the Academic Research Consortium were used to determine definite stent thrombosis. A total of 2077 consecutive patients with ACS undergoing PCI were retrospectively enrolled. Platelet, white blood cell and neutrophil counts, as well as SII, CRP, CAR, and peak cardiac troponin I (cTnI) values were significantly higher, whereas the lymphocyte count and albumin values were significantly lower in the AST (+) group compared with the AST (−) group (P < .05). SYNTAX score showed significant positive correlations with SII (r = .429, P < .001) and CRP (r = .402, P < .001). Multivariate logistic regression analysis showed that SII and CAR, as well as age, diabetes mellitus, stent length, and peak cTnI are independent predictors of AST and high SYNTAX score. In conclusion, the SII and CAR are simple, relatively cheap, and reliable inflammatory biomarkers that can predict AST and high SYNTAX scores in ACS.

No abstract

ÖzÖğrencilerde yalnızlık düzeyinin çeşitli değişkenler açısından incelenmesini amaçlayan bu çalışmamızın araştırma grubu, Ankara Polatlı İmam Hatip Ortaokulu'nda öğrenim gören ve tesadüfi örneklem yoluyla seçilen 88 (% 61,1) kız ve 56 (% 38,9) erkek olmak üzere toplam 144 öğrenciden oluşmaktadır.Verilerin toplanmasında "UCLA Yalnızlık Ölçeği" ve "Kişisel Bilgi Formu" kullanılmıştır. Elde edilen veriler SPSS programında analiz edilerek şu sonuçlara ulaşılmıştır: 'Öğrencilerin yalnızlık düzeyleri üzerinde cinsiyet, sınıf (yaş), okul ortamından memnuniyet, aile ortamından memnuniyet, ailenin gelir düzeyi, öğrencinin birlikte yaşadığı ebeveyn, okuldaki akademik başarı' değişkenlerinin istatistiksel olarak anlamlı düzeyde fark oluşturmadığı tespit edilmiştir.Anahtar Kelimler: Yalnızlık, Eğitim, Öğrenci, Epistemoloji, Niteliksel Loneliness Problem in Students AbstractThe aim of this study is to investigate the level of loneliness in terms of various variables in our students. The study group consists of 144 students, 88 (61.1%) female and 56 (38.9%) male students selected by random sampling from Ankara Polatlı Imam Hatip Secondary School The "UCLA Loneliness Scale" and the "Personal Information Form" were used to collect the data. The obtained data were analyzed in the SPSS program and the following results were obtained: Gender, class (age), satisfaction with the school environment, satisfaction with the family environment, income level of the family, parental cohort of the student, academic achievement in the school did not statistically significant difference on the loneliness levels of the students.

Many hypotheses have been proposed to explain no-reflow (NR). Some of these hypotheses, state that NR may be caused by damage to the vascular endothelium and an inflammatory process. In a recent study that did not include patients with coronary artery bypass graft (CABG), the ratio of C-reactive protein (CRP) to albumin (CAR) was found to be associated with NR. Our study aims to evaluate the relationship between CAR and NR in patients who underwent percutaneous coronary intervention (PCI) for saphenous vein graft (SVG). In this retrospective study, among the patients with CABG who underwent primary or elective coronary angiography, 242 patients who underwent PCI to the SVG were selected. The incidence of NR was 19.8% (n = 48). Diabetes mellitus, left ventricular ejection fraction (LVEF), stent length, and CAR were found as independent predictors of NR in multivariate logistic regression analysis (P < .05). Using a cut-off level of .930, the CAR predicted NR with a sensitivity of 75% and a specificity of 73% (AUC: .814, 95% CI: .749–.879, P < .001). The CAR was a better predictor than both stent length and LVEF. CAR was found to be the strongest predictor of NR in our study.