AbstrakExercise-induced bronchospasm (EIB) sering dijumpai pada atlet remaja. Penelitian untuk mengetahui prevalensi EIB pada atlet remaja di Indonesia belum pernah dilakukan. Penelitian ini dilakukan untuk mengetahui prevalensi EIB pada atlet Sekolah Olahraga Ragunan dengan menggunakan tes latihan di laboratorium. Setiap atlet melakukan latihan sepeda statis (Monark, Swedia) hingga mencapai intensitas latihan minimal pada 90% laju jantung maksimal. "Force expiratory ventilation" (FEV) diperiksa dengan menggunakan spirometri (Minato AS-PAL, Jepang) pada menit ke 0, 5, 10 dan 20 pasca latihan. Diagnosis EIB ditentukan bila terdapat penurunan FEV 1 10% atau lebih dibanding nilai basal. Suhu dan kelembaban ruangan selama penelitian berkisar 28°C-31°C dan 74%-82%. AbstractExercise-induced bronchospasm (EIB) is a common condition among adolescent athletes. There has been no study examining the prevalence of EIB among adolescent athletes in Indonesia. This study aimed to get the prevalence of EIB among Ragunan Sport School athletes by laboratory exercise challenge. Subjects performed static cycle ergometer exercise (Monark, Sweden) to reach minimal workload of 90% maximal heart rate. Force expiratory ventilation (FEV 1 ) was examined by spirometry (Minato AS-PAL, Japan) at minute 0, 5, 10 and 20 post exercise. The EIB was defined as a decline of FEV 1 as much as 10% or more from baseline value. Room temperature and humidity were 28°C-31°C and 74%-82% respectively. There were 168 athletes from 12 sport types who participated in this study. Among them, 23 athletes (13.7%) were EIB positive. The highest percentage of EIB was in taekwondo (54.5%). Sixteen athletes with EIB (70%) were from less asthmogenic sports. Athletes with EIB consisted of 17 (17.5%) females and 6 (8.4%) males. In conclusion, the prevalence of EIB among adolescent athletes was moderately high, and was more prevalent in female. More over, laboratory exercise challenge could elicit EIB in less asthmogenic sport. (Med J Indones 2008; 17: 33-6)

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Umbilical Cord Mesenchyme stem cell (UC-MSCs) /secretome has been applied for treating several diseases, such as cardio-protection and diabetes. Secretome-derived paracrine modulating effects of various growth factors, cytokines, chemokines, angiogenic factors, and exosomes are used in aging therapy. In recent clinical trials on sarcopenia therapy such as pharmaceutical interventions, nutrition, and physical exercise are reported to be effective strategies to reduce sarcopenia. The pathomechanism of the secretome in the treatment of sarcopenia is unclear. This study looked into how secretome might affect myostatin, a biomarker of sarcopenia, at the molecular level. Myostatin, a member of the TGF-family, significantly increases muscle growth when it is absent while suppressing muscle growth when it is present. A bioactive substance called secretome is secreted by MSCs in conditioned conditions. It is rich in growth factors and cytokines, which are crucial for speeding up tissue regeneration. Secretome intervention is a promising approach for treating sarcopenia as showed by its ability to prevent muscle loss and to improve molecular biomarkers.

Introduction: The increase in a person’s age may cause degeneration in their physiological system, and these changes can affect various bodily functions, one of them is the sleep-wake cycle. The elderly usually have disturbed sleep-wake circadian rhythm that can cause sleep problems and decreased sleep quality. The action that can be done to increase sleep quality is doing physical activity. Methods: This research used cross-sectional study design. The respondents were people who reside in Komplek Taman Pulo Indah and Perumahan Aneka Elok aged 60 and older and were not included in the exclusion criteria (n = 204). The instruments used were the Baecke questionnaire to measure physical activity level and the PSQI questionnaire to measure sleep quality. Data analysis was done in univariate and bivariate using chi-square test with significance level of p<0.005. Results: The prevalence of elderly with low physical activity levels and good sleep quality was 33.8%. Meanwhile, elderly with moderate physical activity levels and good sleep quality was 50%, and elderly with high physical activity levels and good sleep quality was 64,7%. Chi-square test was carried out and resulted in p = 0.002 (p<0.005), which meant the null hypothesis was rejected.  Conclusions: There was an association between physical activity level and sleep quality in the elderly.

Low back pain (LBP) has long been recognized as a major health problem. The increasing prevalence of LBP has a negative impact on quality of life, and sosioekonomi. 1 Low back pain in Indonesia often found in the age group of 40 years. The prevalence of low back pain in young people increases with age. When entering the working life can be one risk factor muskulosceletal disorder. 2 Low back pain identified as pain that occurs in the lumbosacral spine and surrounding muscle layers accompanied with or without pain feet. 3 Leg length inquality (LLI) or Leg Length Discrepancy (LLD) is a condition in which both lower limbs are not equal long. 4 A study reports that there are 70% of the normal adult population who show LLD minor, 5 and other studies show that 93% of school children have LLD. 6 LLD is more than 10mm can cause biomechanical disorders such as scoliosis, joint pain back and lower extremities, pelvic tilt, abnormal gait and degenerative joint disease that prematur. 7 Inequalities that occur limb length can cause dysfunction and pain, including low back pain. MethodThis study is an observational study (non experimental) by means of data capture cross -sectional and how conclusions descriptively and analytically. The independent variable is the leg length discrepancy and the dependent variable is low back pain. The study was conducted in January and July in the academic year 2017-2018 Faculty of Medicine, University of Atma Jaya.