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The article investigates the ways and means of improving and perfecting the occupational safety management system at the enterprises of Ukraine with the help of modern international standards. A detailed analysis of the new international standard ISO 45001 on safety, as well as a model for improving the management system of labor protection at the enterprise. The object of research is international standards for occupational safety and health management. The purpose of the work is to analyze the implementation of a new international standard on occupational safety with the development of a new model of occupational safety management at the enterprise. Research methods – analytical. Quality management of labor protection at enterprises is one of the priority activities of enterprises in order to reduce occupational injuries, improve working conditions and microclimate in the enterprise. In order to effectively manage occupational safety at enterprises, the authors of the article propose the introduction of a new model of occupational safety system management in accordance with the international standard ISO 45001. The research consists in determining the correct approach to the organization of the labor protection system at the enterprises of Ukraine by applying modern international standards for occupational safety and health management, modeling processes to improve the state of labor protection at enterprises The results of research can be recommended for implementation in the management system of labor protection at enterprises of Ukraine.