Patients with pre-existing comorbidities and immunosuppression are at greater risk for SARS-CoV-2 infection and severe manifestations of COVID-19. This also includes cancer patients, who are shown to have a poor prognosis after infection. Here, we describe the case of a 72-year old male patient with B-cell depletion after maintenance treatment with rituximab for non-Hodgkin-lymphoma who had a prolonged COVID-19 course and initial false negative test results. Our case highlights the diagnostic pitfalls in diagnosing COVID-19 in B-cell depleted patients and discuss the role of B-cell depletion in the course and treatment of COVID-19. Furthermore, we investigated peripheral blood monocytes and SARS-CoV-2 specific T cells in our patient. In conclusion, our case report can help physicians to avoid diagnostic pitfalls for COVID-19 in hemato-oncological patients under chemoimmunotherapy and tries to explain the role of B-cell depletion and SARS-CoV-2 specific T cells in this context.

Background: Benzbromarone is a uricosuric drug that has been used in the treatment of gout over the last 30 years. Due to its potent inhibition of the dominant apical (luminal) urate exchanger in the human proximal tubule URAT1, it reduces the urate reabsorption, diminishing serum urate levels and therefore preventing gout flares. Main body of the abstract: Through several clinical trials, Benzbromarone has been proved effective and safe, inclusive in patients with chronic kidney disease and as combination therapy with allopurinol. Due to hepatotoxicity reports, it was withdrawn from the European market by the manufacturer, however many authors have questioned the product's withdrawal due to a lack of clinical evidence in order to support its hepatotoxicity. Benzbromarone is still available in several European countries, New Zealand, Brazil and several other countries. Despite the product's marketing over more than 20 years after the first hepatotoxicity reports, we have found only five reports in our literature search, and no prospective or retrospective study correlating hepatotoxicity with benzbromarone use. Short conclusion: Benzbromarone is a safe and effective molecule for the treatment of gout. However, due to in vitro and in vivo data related to hepatotoxicity, it is prudent to prescribe it with some caution, especially for patients with an already known liver condition.

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The aim of this study was to investigate possible effects of two hypothetical scenarios of the urbanization of Zagreb's surroundings on the local winds, which are established under summertime anticyclonic conditions. For this purpose, the nonhydrostatic mesoscale meteorological model MEMO was applied to the greater Zagreb area. Three simulations were performed. One employed the current land-use distribution, while the other two corresponded to an increase of the densely urbanized area by 12.5% (test 1) and 37.5% (test 2), respectively. Apart from the hypothetically urbanized areas, where average surface wind speed reductions of 8% and 18% were obtained for test 1 and test 2, respectively, the rest of the domain was not signi®cantly affected by hypothetical urbanization. The differences between the wind vectors for the predicted current state and the hypothetical state were more pronounced and found at higher altitudes during the night compared to daytime values. For all three simulations the same diurnal variation of the depth of anabatic=katabatic wind¯ow generated on south-facing slopes of 1 km high mountain Medvednica was obtained. During the night the depth of well-developed katabatic¯ow was about 370 m, while during the day the depth of anabatic ow grew from about 550 m in the late morning up to about 1140 m in the late afternoon.