Objective: In this study, the relationship between changes in mean platelet volume (MPV) and erythrocyte distribution width (RDW) with hematological response and survival in patients with myelodysplastic syndrome was investigated. Patients and Methods: Between 1 January 2011 and 31 December 2018, patient characteristics and hemogram results were evaluated during the treatment process among 158 patients diagnosed with myelodysplastic syndrome. Results: The mean age of the patients who were included in the study was 71.53±12.6 years. The MPV percentage change in the 2-year follow-up of the patients with and without hematological response was significant, at 0.022±0.11 (2.2%) in those who responded and at 0.069±0.15 (6.9%) in those who did not (p=0.049). Throughout the same period, the degree of RDW changes in the patients who died was 13.23±22.97, the degree in those who survived was 2.86±21.42, and the difference between the two groups was statistically significant (p=0.006). Conclusion: In patients diagnosed with myelodysplastic syndrome, MPV and RDW values can be considered inexpensive and simple laboratory markers that can be used in follow-ups and promising tests to predict both treatment response and survival in the early period and change treatment modalities.