Background: Coronary heart disease (CHD) is a leading cause of death worldwide. One type of CHD that most often causes clinical manifestations and death is Acute Coronary Syndrome (ACS). In 2013 the prevalence of SKA in Indonesia reached 1.5% and it is estimated that it will continue to increase every year. Objective: This study aims to determine the profile of major risk factors for ACS sufferers in the Pusat Pelayanan Jantung Terpadu (PPJT) Dr. Soetomo Public Hospital Surabaya in the period January-December 2019. Methods: This study used a retrospective descriptive method to analyze the patient's electronic medical record (e-MR). Results: Out of 623 patients diagnosed with ACS, 429 were excluded from the research. 194 patients who met the inclusion criteria were studied with the following details: 19 APTS patients, 43 N-STEMI patients, and 132 STEMI patients. It was found that 73% of ACS patients were male, with the 55-64 years’ age group dominating by 46%. Based on blood pressure and serum cholesterol examination data, it was found that 51% of patients had hypertension and 77% of patients had dyslipidemia (40% hypercholesterolemia, 42% hypertriglyceridemia, 40% low HDL-C levels, and 34% high LDL-C levels). 60% patients had type-2 diabetes mellitus and 52% of patients had a history of smoking. Conclusion: 73% of ACS patients in this study were men. Most common age groups were 55-64 years old (46%), had hypertension by 51%, had dyslipidemia by 77% (40% hypercholesterolemia, 42% hypertriglyceridemia, 40% low HDL-C levels, 34% high LDL-C), had type-2 diabetes mellitus by 60%, and had a smoking history by 52%.

Hypertension is a leading cause of death worldwide including in Indonesia. The World Health Organization (WHO) estimates that currently the global prevalence of hypertension is 22% (WHO, 2019). In 2018 the prevalence of hypertension in Indonesia reached 34,11% (Riskesdas, 2018). Every year, it is estimated that 10.4 million deaths are caused by hypertension (Unger et al., 2020). Hyperbaric Oxygen Therapy (HBOT) is a therapy with pure oxygen concentration (100%) in a high pressure room (Ortega et al., 2021). In previous studies it was found that HBOT improves the effects of vasodilation (Mihaljevic et al., 2018). However, other studies mention different results. It was found that HBOT initiates vasoconstriction and increases systemic vascular resistance. This causes a decrease in nitrite oxide (NO) production and increase NO oxidation (Goyal et al., 2021). Apart from a variety of different study results, the use of HBOT has indeed been widely studied even though it has not found a clear meeting point on the effects of blood pressure reduction on hypertension patients. Therefore, the author aims to find out more clearly the mechanism and benefits of hyperbaric oxygen therapy against decreased blood pressure in hypertension patients.