Introduction:The comorbidity between headaches and psychiatric disorders is common and may be explained by different mechanisms in terms of uni or bi-directional models, or sharing of genetic and environmental risk factors relating to development of both clinical conditions. The presence of this comorbidity has important implications for patients with headaches and for patients with psychiatric disorders, worsens the clinical situation, increases the risk of chronicity, the pain intensity and the rate of treatment failure. Material and Methods:The authors performed a descriptive, retrospective study of prevalence, involving 250 patients seen in Psychiatry -Headaches liaison consultation, over a period of 3 years, from July 1, 2011 to July 1, 2013. The authors undertook the analysis of the clinical records, in respect to sociodemographic and clinical data, neurological and psychiatric diagnosis and prescribed therapy. Results and Discussion: During this period were made 689 liaison consultations, with a prevalence of female patients (84%) and a mean age of 47 years. The tension type headache (60.8%), migraine (24.8%) and headache attributed to psychiatric disorders (7.2%) were the most prevalent types of headaches. Mood disorders (62%) and neurotic stress related disorders (39.2%) were the most frequent psychiatric diagnoses. The therapeutic intervention in these cases emphasizes the multidisciplinary approach with the collaboration of Neurologist and Psychiatrist, based in psychoeducation, cognitive-behavioral intervention and psychopharmacological treatment. Conclusion:Given the complexity of the clinical picture in cases of comorbidity, the experience of psychiatry liaison consultation and multidisciplinary intervention has proved particularly valuable in treating these patients, configuring itself as the proper treatment of this comorbidity. Keywords: Comorbidity; Headache; Mental Disorders; Psychiatry. INTRODUÇÃOSegundo a Classificação Internacional de Cefaleias da Sociedade Internacional de Cefaleias (ICHD-3 beta),1 estas podem ser divididas em Cefaleias primárias, ou cefaleias secundárias quando ocorrem pela primeira vez em estreita relação temporal com outra alteração que é uma causa reconhecida de cefaleias.As cefaleias primárias compreendem a enxaqueca com ou sem aura, as cefaleias tipo tensão e a cefaleia em salvas, o tipo mais conhecido das cefaleias trigémino-autonómicas. As cefaleias secundárias podem ser devidas a situações de traumatismo crânio-encefálico e/ou cervical, doença vascular craniana ou cervical, perturbação intracraniana não vascular, uso de substâncias ou sua privação, infecção, perturbação da homeostase, perturbação de estruturas cranianas ou faciais e perturbações psiquiátricas. Por fim a parte 3 engloba as neuropatias cranianas dolorosas, outras dores faciais e outras cefaleias.As cefaleias primárias são geralmente conceptualizadas

Quetiapine in an atypical antipsychotic drug that is frequently used for delirium and behavioral and psychological symptoms in dementia. However, its potential anticholinergic effects, mediated primarily through its metabolite norquetiapine, could present as counterproductive adverse effects in these situations. There is little data published discussing this potential negative impact on quetiapine’s safety and tolerability, especially in the elderly. Here, we present what is, to our knowledge, the first published case report of delirium apparently induced by low-dose quetiapine, in a 95-year-old patient with no prior history of mental illness, and the potential role of its metabolite norquetiapine.

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BACKGROUND AND AIMSDepression is the leading cause of disability worldwide, with an estimated prevalence of 322 million (4.4% of the world population). The common occurence and persistance of such a phenomenon is difficult to explain. Evolutionary approaches might be useful as overarching frameworks for unified models of depression and generate interesting hypotheses for research. METHODSA systematic review of the literature available was conducted on Pubmed and the studies found were grouped according to several hypotheses. CONCLUSIONSEvolutionary models may offer a way to combine apparently disparate pieces of evidence on depression, be useful as overarching frameworks for unified models of depression (Aaron T. Beck et. al, 2016figure 1) and generate interesting hypotheses for research.