Imène Sehout scite author profile

International audienceAn efficient one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via a three-component Biginelli condensation of aldehyde, ethyl acetoacetate, and urea or thiourea in the presence of a catalytic amount of ascorbic acid (5 mol %) is described. The reaction proceeded efficiently under solvent-free conditions at 80 °C to afford the desired products in moderate to good yields

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Facile Synthesis, Crystal Structure, Hirshfeld Surface Analysis, DFT Calculation and in vitro Antifungal Evaluation of 4-Arylidene-1H-pyrazol-5(4H)-ones

Nemouchi

Sehout

Boulebd

et al. 2023

Organic Preparations and Procedures International

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ChemInform Abstract: Ascorbic Acid‐Catalyzed One‐Pot Three‐Component Biginelli Reaction: A Practical and Green Approach Towards Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones/thiones.

Sehout¹,

Boulcina²,

Boumoud³

et al. 2013

ChemInform

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Imène Sehout

Solvent-free synthesis of polyhydroquinoline and 1,8-dioxodecahydroacridine derivatives through the Hantzsch reaction catalyzed by a natural organic acid: A green method

Synthesis, crystal structure, Hirshfeld surface analysis, biological evaluation, DFT calculations, and in silico ADME analysis of 4-arylidene pyrazolone derivatives as promising antibacterial agents

Ascorbic acid-Catalyzed One-Pot Three-Component Biginelli Reaction: A Practical and Green Approach towards Synthesis of 3,4-dihydropyrimidin- 2(1H)-ones/thiones

Facile Synthesis, Crystal Structure, Hirshfeld Surface Analysis, DFT Calculation and in vitro Antifungal Evaluation of 4-Arylidene-1H-pyrazol-5(4H)-ones

ChemInform Abstract: Ascorbic Acid‐Catalyzed One‐Pot Three‐Component Biginelli Reaction: A Practical and Green Approach Towards Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones/thiones.

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