Objective: To observe the results of syndromic management in women living in IDPs camps complaining of chronic vaginal discharge. Design: Descriptive study. Setting: Medical Camps at Larkana set by Chandka Medical College Hospital for Internally Displaced Persons (IDPs) due to floods. Period: 1st September 2010 to 31st December 2010. Material and Methods: Total 200 symptomatic patients aged from 20 to 50 years suffering from chronic vaginal discharge having history of more than 6 months duration were included in the study. Asymptomatic as well as pregnant women and patients with abnormal cervix and having abnormal growth on cervix were excluded from the study. A detailed history and examination (including speculum and vaginal) was done and a proforma was filled. All these patients were given empirical treatment recommended by WHO as syndromic management consisting of stat doses of antifungal along with antibiotics, where no laboratory tests are required before treatment. Results: Next to vaginal discharge which was main symptom in all patients, the other symptoms like dusparunia, dysuria, itching ,lower abdomen pain and low backache was reported 9%, 16%, 20%, 24% and 31% respectively. Also 8% patients reported post coital bleeding. All patients were married and the mean age of the patients was 28+0.2 years and 15% of them were over 40 years. Mean parity was 4±1.Vaginal infection improved in 65% of the patients excellently with a first line single course of antibiotic and percentage raised up to 88% with second course. 19(9.5%) patients couldn’t be followed as they left that camp and 5(2.5%) patients who did not improve with two courses of antibiotics had big cervical erosions, referred to nearby tertiary care hospital for further management. Conclusions: IDPs live in poor conditions in camps without basic facilities and where it is difficult to perform bedside tests like microscopy, Potassium Hydroxide, wet mount films and tests for Sexually transmitted diseases like Chlamydia and gonorrhea are not available, syndromic management there is a rational way of treating cases of chronic vaginal discharge to get quicker response in such desperate women.

Background: When pre-eclampsia (PE) occurs, it is a multi-organ condition with an unknown cause that is classified as a high-risk pregnancy marked by hypertension and proteinuria. Many antihypertensive medications are utilised, but they have drawbacks, whereas the use of labetalol to treat hypertension in women with pre-eclampsia has shown to be effective. Our findings may aid in underlining the importance of adequate treatment for pre-eclamptic patients who are in danger. Objective: To evaluate the effectiveness of intravenous labetalol in the treatment of pre-eclampsic pregnant women who presented to a public service tertiary hospital. Study Design: Descriptive study. Place and Duration of Study: Department of Obstetrics and Gynecology, Shaikh Zaid Women Hospital, Larkana from 1st June to 30th November 2020. Methodology: One hundred women with pre-eclampsia who had a singleton pregnancy on ultrasonography. Then intravenous labetalol 20mg, 40mg, 80mg, then 80mg every 15 minutes until goal blood pressure was obtained. Every 30 minutes, blood pressure was taken. Results: The mean age was 31.25±5.30 years. There were 24% patients with pre-eclampsia achieved target blood pressure (150/100 mmHg) with one dose of intravenous labetalol, another 55% achieved target blood pressure with a second dose, and the remaining 21% achieved target blood pressure with a third dose. Conclusion: Labetalol was found to be an effective treatment for women suffering from pre-eclampsia. Keywords: Pre-eclampsia, Blood pressure, Intravenous labetalol

Background: Infertility is always been considered as social issue because of its impact on individuals as well as on families. Unexplained infertility defined as inability of a couple to conceive after one year of unprotected intercourse even in the absence of any specific reason for it. Aim: To compare the efficacy of letrozole and clomiphene citrate among patients presenting with unexplained infertility Study design: Prospective observational study. Place and duration of study: Department of Obstetrics & Gynecology, Sheikh Zayed Women Hospital Larkana from 1st January 2020 to 31st December 2020. Methodology: Three hundred and thirty six women having unexplained infertility were randomly allocated into two groups. One hundred and sixty eight patients in group A were given letrozole 2.5mg and 168 women in group B received clomiphene citrate 50mg for three months with successive increase in dose up to 3 cycles, if not conceived in first cycle. They were assessed for pregnancy after 4, 8 and 12 weeks of treatment. Results: The average age of the patients was 27.01±2.53 years. Efficacy of letrozole was significantly high as compare to clomiphene citrate [82.1%vs.62.5%;p=0.0005]. Conclusion: The efficacy of letrozole was significantly high as compared to clomiphene citrate. Letrozole is a better alternative for ovulation induction in anovulatory women because it has high pregnancy rates with shorter time to pregnancy and chances of multiple pregnancies are less because of high monofollicular growth. Keywords:-Infertility, Clomiphene citrate, Letrozole, Unexplained infertility.