Introdução: As plantas medicinais são capazes de fornecer fármacos de grande importância clínica, a exemplo dos monoterpenos. Estes são conhecidos por apresentarem uma variedade de efeitos em diferentes sistemas biológicos, justificando a necessidade de pesquisas para investigação do potencial terapêutico e tóxico. Com o avanço tecnológico, modelos in silico vêm sendo amplamente aplicados para a avaliação de potenciais atividades farmacológicas e de toxicidade de compostos em ambientes metabólicos de mamíferos.  Objetivo: Avaliar os efeitos farmacológicos e toxicológicos do monoterpeno Neral com finalidade odontológica, utilizando uma metodologia in silico. Metodologia: Inicialmente utilizou-se o software Pubchem® para o desenho da molécula, em seguida a análise da probabilidade da atividade da molécula foi realizada com o software Pass Online®. Na análise dos parâmetros farmacológicos, foi avaliado a biodisponibilidade oral teórica do Neral, pela “Regra dos Cinco” de Lipinski com o software Molinspiration Cheminformatics. Finalmente, os parâmetros toxicológicos bem como o estudo teórico sobre o efeito carcinogênico, o teste de AMES e a toxicidade oral aguda foi efetuada no programa admetSAR. Resultados e Conclusão: No Pass Online a molécula do Neral possui 14 possíveis atividades farmacológicas relacionadas à Odontologia, dentre elas potencial antifúngico, anti-inflamatória e antibacteriana; no Molinspiration a molécula do Neral demonstrou estar de acordo com as cinco regras propostas por Lipinsk, logo, apresentando boa biodisponibilidade oral teórica e, pelo teste de toxicidade do admetSAR, apesar de apresentar baixo risco de toxicidade teórica oral, revelou leve potencial carcinogênico.Descritores: Disponibilidade Biológica; Toxicidade; Plantas Medicinais; Odontologia.ReferênciasLima GR. 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Introduction: sialochemical studies demonstrate that saliva has biomolecular proportions similar to blood, and can function as a means of diagnosing cardiovascular diseases whose factors are dyslipidemia. Objective: To assess the correlation between blood lipid concentrations and saliva. Methodology: The unstimulated saliva of 40 dentistry students, ages 18 to 29, both genders, was collected by the modified Navazesh method, then centrifuged. A venipuncture for blood collection was performed, then the blood was centrifuged and the serum separated. Labtest® kits were measured for salivary and blood cholesterol and triglycerides using the colorimetric enzymatic method. Statistically, paired Student's t-test and Pearson's correlation test were used. The results were expressed as mean more or less the standard error of the mean (e.p.m). Graph Pad Prism software version 6.01 was used. Results: 72.5% of the participants were female and 27.5% male, the average age was 21.55 ± 0.41 for the female gender and 21.64 ± 1.07 for the male. The average age of individuals of both genders was 21.63 ± 0.41 years. Sialometric data showed an average salivary flow of 0.71 ± 0.15 ml / min. The values of cholesterol and salivary triglycerides were significantly lower when compared to serum values and there was no correlation between these parameters. Conclusion: Saliva showed lower cholesterol and triglyceride concentrations than blood, with no significant correlation of these lipids between fluids.