One of the most commonly known genes involved in chronic diffuse liver diseases pathogenesis are genes that encodes the synthesis of glutathione-S-transferase (GST), known as the second phase enzyme detoxification system that protects against endogenous oxidative stress and exogenous toxins, through catalisation of glutathione sulfuric groups conjugation and decontamination of lipid and deoxyribonucleic acid oxidation products. The group of GST enzymes consists of cytosolic, mitochondrial and microsomal fractions. Recently, eight classes of soluble cytoplasmic isoforms of GST enzymes are widely known: α-, ζ-, θ-, κ-, μ-, π-, σ-, and ω-. The GSTs gene family in the Human Gene Nomenclature Committee, online database recorded over 20 functional genes. The level of GSTs expression is considered to be a crucial factor in determining the sensitivity of cells to a broad spectrum of toxins. Nevertheless, human GSTs genes have multiple and frequent polymorphisms that include the complete absence of the GSTM1 or the GSTT1 gene. Current review supports the position that genetic polymorphism of GST genes is involved in the pathogenesis of various liver diseases, particularly non-alcoholic fatty liver disease, hepatitis and liver cirrhosis of different etiology and hepatocellular carcinoma. Certain GST allelic variants were proven to be associated with susceptibility to hepatological pathology, and correlations with the natural course of the diseases were subsequently postulated.

The study of the role of Moodle software among medical students is relevant, as distance learning is now new in terms of learning, processing, and teaching educational material online. The representation of new (latest) informative data using Moodle during distance learning contributes to and increases the level of students' knowledge. Moodle software is a valuable resource that presents an archive of educational (scientific) materials to students and teachers with unlimited access. The study is aimed at determining the role of Moodle for medical students during distance learning based on a theoretical review of the literature. Three stages of methodological justification were proposed as the basis for this study. At the first stage of the study, Moodle software was characterised; during the second – the role of distance learning was defined; third – the quality of medical students' training during distance learning through the use of innovative technologies, namely Moodle, was assessed. The study substantiates the significant role of Moodle and distance learning: understanding the goals of learning, gaining a significant “baggage” of knowledge, the latest information and access to resources, self-learning, self-improvement, and development of a “doctor” personality. The expediency of using the software among medical students is proved, taking into account the structure, logic, constant updating of materials, direct assessment of the student using test tasks and practical classes. Using Moodle software during distance learning, a medical student independently and consciously focuses on pathology based on the acquired knowledge, clearly and reasonably makes a preliminary conclusion (diagnosis) with subsequent appropriate treatment. The combined use of Moodle software and highly qualified teachers improve the quality of education and guide the medical student to focus on the study material and improve one’s practical skills with the presented materials and visual aids

Among medical students, deduction remains the main method in making a diagnosis or diagnostic conclusion after examining patients or their detailed examination. This method gives the opportunity to clearly and objectively formulate an opinion and assess the patient's condition according to the diagnosis. Therefore, deduction and its methods are relevant both among medical students and among medical staff. The role of application of the deductive method among medical students is substantiated. It is established that the application of deduction while studying in a medical higher educational institution will allow influencing the already developed personality of the student and developing in him or her the “building” type of personality orientation. Therefore, this method constitutes a topical issue of today. The purpose of the study is to evaluate the specific features of the deductive method among medical students based on literature analysis. To implement the goals and objectives, three stages of studying the features of the deductive approach among medical students were proposed. In the first stage of the research the role of deduction in the educational process, its advantages and disadvantages were determined by means of processing the literature according to the method of analysis and synthesis; during the second stage the types of personality, ways of influencing its development are determined, the interrelation between the type of personality and its level of thinking is traced; The third stage of the study included the assessment of deductive methods that allow students to form clarity and correctness of action, as well as to develop students' thinking by setting a position, justifying it with an example and forming a conclusion. The study identified the essential role of the deductive method among medical students in the development of personality orientation and development of mental activity. It is found that the use of the PRESS method will make it possible to clearly define the position, justify the result, and draw a correct conclusion (diagnosis), which is mandatory in the analysis of pathological conditions in medicine. Proper pedagogical education allows obtaining the desired result. By adhering to the criteria of teaching material, such as conceptuality, logic of the process, system, controllability, efficiency, and reproducibility, the teacher will attract the attention of a medical student and interest him or her in analysing the subject

Abstract.  Recent data on the role of digestive pathology in the progression of chronic kidney disease (CKD) remain scarce. Calcium homeostasis plays an important role in the progression of renal pathology, especially in patients with malabsorption syndrome (MAS). The research aimed to evaluate calcium homeostasis in CKD patients with MAS. Methods. In this cross-sectional observational study, 99 CKD patients with MAS were enrolled. The patients were divided into 4 groups according to the CKD stage and the presence of MAS. Group I included 25 patients with CKD stages 1 and 2 without MAS; Group II consisted of 26 patients with CKD stages 1 and 2, and MAS; Group ІІІ (n = 23) and Group ІV (n = 25) included patients with CKD stage 3 without and with MAS, respectively. According to the morphological study of in vivo biopsies of the small intestinal mucosa, mild and moderate morphological changes were observed among all patients. The levels of calcium, phosphorus, parathyroid hormone, osteocalcin, and calcitonin in the blood, as well as urinary calcium levels, were detected. Results. Pathological changes in calcium metabolism were observed among CKD patients with MAS. The severity of calcium homeostasis disorders was more evident among patients with CKD stage 3 compared with stages 1 and 2. Urinary calcium levels were reduced in the patients of Groups III and IV. No changes were detected in phosphorus levels. Changes in parathyroid hormone and osteocalcin are caused primarily by combined renal pathology with impaired renal calcium absorption. Conclusion. MAS in CKD patients leads to deep violations of calcium homeostasis resulting in rapid CKD progression and bone tissue violation.