North-east India is one of the highly affected region by mosquito-borne diseases. MBDs cause major hindrance in the lives as well as survivability of people here. The most reported mosquito vector-borne diseases here are Malaria, Dengue, Japanese encaphalities, Lymphatic filariasis and Chikungunya to name a few. While the hot and humid climate is one of the factor for widespread distribution of mosquito species in North-eastern states, it is also bestowed with abundant medicinal plants which can be used for the treatment of MBDs. The long-standing innate connection between the ethnic groups and the environment, particularly with plants, has given contemporary civilization access to a wide range of herbal treatments. This study mainly focuses on the present scenario of MBD in north-eastern states of India and the therapeutic uses of plants endemic to this region which have medicinal properties to cure or prevent such diseases.

The study is to use AutoDock software to determine the binding affinity or binding energy of DEET, picaridin, prallethrin, and IR3535 components with the odorant receptor of the Anopheles gambiae say (Diptera, Culicidae) mosquito species. The binding energy (ÄG) of prallethrin was determined to be highest at -10.55 kcal/mol followed by picaridin at -7.1 kcal/mol, DEET at -6.57 kcal/mol and IR3535 at -5.6 kcal/mol being the lowest among all. By comparing their binding energy levels after AutoDocking, it is to decide which mosquito repellent is the most effective.

No abstract