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Neuropathic pain is a debilitating symptom reported by patients presenting with postherpetic neuralgia (PHN). Efforts to alleviate this pain have been projected to lie in individualization of pharmacological treatment through pain phenotyping and subsequent investigations into the genetic basis of PHN therapy. Understanding the various mechanisms related to these phenotypes can aid in improvement of available treatment options and discovery of new ones. Knowledge and application of genetic variations in PHN, structural proteins, and genes can aid in ascertaining risk, susceptibility to, severity of, and protection from PHN. This review summarizes the most recent information that has been published on phenotypes and genotypes with possible clinical applications and directions for future research.

Introduction Knowledge of anatomical variations in the origin and in the course of the dorsal metatarsal arteries (DMTAs) is valuable for many procedures, including reconstructive surgeries and flap selection. However, there is a paucity of data on these arteries among black Africans. Materials and Methods The present study studied the origin and the location of DMTAs in 30 formalin-fixed cadaveric feet of adult black Kenyans at the Department of Human Anatomy of the University of Nairobi, Nairobi, Kenya. Results Dorsal metatarsal arteries were present in all of the cases. Of the right dorsalis pedis artery (DPA), in the majority of the cases, the 1st DMTA arose as the continuation of the DPA, while the 2nd to 4th DMTAs were given off as branches from the arcuate artery (AA). On the left feet, in the majority of the cases, the 1st DMTA arose as the continuation of the DPA, while the rest were given off as branches from the AA. In relation to the dorsal interossei muscles, all of the the arteries were either within the muscle fibers (53%) or beneath them (47%), on the right side. On the left side, the 1st DMTA was above the muscles in 40% of the cases; within the muscles in 53%; and beneath the muscles in 7%. The 2nd and 3rd DMTAs were above the muscles in 57% and in 53% of the cases, respectively. Conclusion These results reveal that the DMTAs show variation in their origin and position relative to the dorsal interossei muscles. These variations display bilateral asymmetry.

Background: The calcaneus exhibits variations in articular facets and calcaneal sulcus width. These variations influence occurrence of osteoarthritic conditions, whose prevalence is significant in our setting, and are essential during surgeries involving the foot. Despite this, local data on calcaneal facets remain scarce. Methods: Sixty calcanei were obtained from the National Museum of Kenya. The number, type and shapes of their facets were documented and calcaneal sulcus width measured. Images were taken and collected data were represented in tables and figures. Results: The calcanei had 1–3 articular facets. The common calcanei type noted was type 1B on the right calcaneus and 1B on the left. The least was type 4 on the right and 2C on the left. In terms of shape, types 1 and 4 calcanei had non-rounded facets while type 2 had rounded facets. The width of the sulcus calcanei was narrowest among type 1 calcanei in the right foot at 0.53 cm. On the left foot, type 2 calcanei had narrower (0.455 cm, range 0.35–0.60) calcaneal sulcus width. Conclusion: Our findings may aid in surgeries of the foot and in providing a link between local calcaneal variations and prevalence of osteoarthritic foot conditions. Keywords: Calcaneal-facets, Sinus tarsi, Arthritis

Objective To describe the relationship between number and distribution of valves. Methods Sixty-six popliteal vein specimens were used for the study after routine dissection at the Department of Human Anatomy, University of Nairobi. The extents of the popliteal vein were identified at the adductor hiatus and soleal arch, cut at these points and then longitudinally sliced open. The number and distribution of valves were then recorded. Data were presented using photomacrographs and tables. Results The median number of valves was 1 (mean 0.8; range 0–2), with the lower part of the popliteal vein as the most consistent valve position. Most striking was the valve absence noted in 27 (41%) of the veins. Conclusion These findings suggest that a significant proportion of popliteal veins do not have valves thus providing a credible structural link that may predispose the popliteal vein to deep venous thrombosis in the study population.