Some studies suggest that periodontal diseases increase the risk of oral cancer, but contradictory results also exist. Inadequate control of confounders, including life course exposures, may have influenced prior findings. We estimate the extent to which high levels of periodontal diseases, measured by gingival inflammation and recession, are associated with oral cancer risk using a comprehensive subset of potential confounders and applying a stringent adjustment approach. In a hospital-based case-control study, incident oral cancer cases (N = 350) were recruited from two major referral hospitals in Kerala, South India, from 2008 to 2012. Controls (N = 371), frequency-matched by age and sex, were recruited from clinics at the same hospitals. Structured interviews collected information on several domains of exposure via a detailed life course questionnaire. Periodontal diseases, as measured by gingival inflammation and gingival recession, were evaluated visually by qualified dentists following a detailed protocol. The relationship between periodontal diseases and oral cancer risk was assessed by unconditional logistic regression using a stringent empirical selection of potential confounders corresponding to a 1% change-in-estimates. Generalized gingival recession was significantly associated with oral cancer risk (Odds Ratio = 1.83, 95% Confidence Interval: 1.10-3.04). No significant association was observed between gingival inflammation and oral cancer. Our findings support the hypothesis that high levels of periodontal diseases increase the risk of oral cancer.

Four hundred and twenty-six cases of verrucous carcinoma of the oral cavity were detected jointly by the per cent of 7988 primary malignant neoplasms of the oral cavity detected during the period. There were 276 men and 150 women with an average age of 67.5 years. The maximum incidence was noted in the sixth decade of life. The highest incidence was observed in the buccal mucosa, followed by tongue, alveolus, and lips. These patients had no associated malignancies but leukoplakia was observed consistently in all cases. All had chewing and/or smoking habits. Most of the patients were treated surgically. Twenty-six patients reporting back with recurrence were given radiotherapy and followed for a period of 30 months. Among the 26, 18 patients showed recurrence at the local site. Surgery seems to be the treatment of choice for verrucous carcinoma. The aetiopathogenesis of the tumour is discussed.

Intraosseous mucoepidermoid carcinoma of jaw bones is a rare lesion. Abundance of clear cells in an intraosseous mucoepidermoid carcinoma may complicate its histopathologic diagnosis. It becomes extremely important to distinguish this lesion from other clear cell lesions of jaw region. Here, we report a case of clear cell variant of intraosseous mucoepidermoid carcinoma in the mandible.

Necrotizing sialometaplasia, is a benign inflammatory lesion primarily involving the minor salivary glands of the hard palate. The lesion often presents itself as a deep-seated palatal ulcer with clinical and histological features similar to those of a malignant neoplasm. Here we report a case of necrotizing sialometaplasia in a 40-year-old female, present on the lateral border of the tongue, mimicking squamous cell carcinoma, clinically. A correct diagnosis to avoid mutilant surgical treatments is essential, considering that it is a self-limiting disease.

ABSTRACT:Objectives: Paan chewing is a recognized risk factor for oral cancer in the Asian population. However, there is currently little evidence about the intergenerational psychosocial transmission of paan chewing in South Indian families. We investigated the association between parental and participant's paan chewing in a South Indian population.Methods: A subset of data was drawn from a hospital-based case-control study on oral cancer, the HeNCe Life study, conducted at Government Dental and Medical Colleges of Kozhikode, South India. Analyses were based on 371 non-cancer control participants having diseases unrelated to known risk factors for oral cancer. Demographics, behavioural habits (e.g., paan chewing, smoking), and indicators of socioeconomic position (SEP) of both participants and their parents were collected with the use of a questionnaire-based interview and a life grid technique. Unconditional logistic regression assessed odds ratios (OR) and 95% confidence intervals (95%CI) for the associations between parental and participant's paan chewing, adjusted for confounders.Results: Over half of the participants were male (55.2%) and the mean age of participants was 59 (SD=12) years. After adjusting for age, religion, parents' SEP, parents' education, smoking and alcohol consumption, and perceived parenting behaviour we observed that maternal and paternal paan chewing were significantly associated with the participant's paan chewing (OR=2.40, 95%CI=1.11-5.21) and (OR=3.05, 95%CI=1.48-6.27), respectively. Conclusions:Intergenerational psychosocial transmission of the habit of paan chewing could occur through shared socio-cultural or environmental factors.