Introduction: Malignant melanoma is a common tumor whose incidence is increasing. The most common form of intestinal metastasis of melanoma is submucosal implant. Intussusception, which is most often secondary in adults, can occur on melanoma metastasis. Computed tomography (CT) is the test that confirms intestinal obstruction due to intussusception. Case Report: We report the case of a 47-year-old female patient, with history of malignant scalp melanoma. She was admitted to the emergency room of the hospital in a clinical picture of small intestine occlusion. On clinical examination, she had a distended and painful abdomen. Abdominal-pelvic CT showed an entero-colic invagination on the right iliac fossa. There was no evidence of ischemia of small bowel nor colic. Conclusion: A nodular endoluminal form of melanoma metastasis can lead to intestinal invagination. Therefore, it is worthwhile to look for it in case of clinical picture of intestinal obstruction in a patient with history of melanoma.

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