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Background: "Polycystic Ovary Syndrome" (PCOS) has been identified as a hazard for growing diabetes. Although it indicates and symptoms of "Polycystic Ovary Syndrome" (PCOS) appear before the signs and symptoms of "Insulin resistance" (IR) first, According to an assumption "Insulin resistance" (IR) may have a part in developing PCOS instead of another factor. Insulin resistance caused by obesity modifies the function of the pituitary gland and hypothalamus in the brain, leading to an increase in the synthesis of androgenic hormones, which correlate to PCOS1. Aim: To analyze outcomes of insulin resistance in women having polycystic ovaries Methodology: A literature search was performed with the use of search engines. The following search engines provided the articles for this systematic review, PubMed, Medscape, NCBI, and Google Scholar. For article searching following keywords were used; Polycystic ovaries, insulin resistance. Results: As a literature review of 45 articles and only 39 were included in this review, it is found that the Mean age of all subjects was 24-37 years. Obese females were 20-30 years and non-obese were 18-34 years. Insulin resistance occurs in 70-95% of females who were obese and had PCOS and 30-75% of females who were lean and developed PCOS. Hirsutism was observed mostly in obese patients diagnosed of having PCOS. Incidence of Amenorrhea was found higher in lean patients. Conclusion: It is concluded that high insulin is not just a symptom of PCOS it's also one of the major drivers of this condition. Insulin resistance acts as a key factor of PCOS. It mostly occurs among people who are obese and had developed PCOS. Keywords: (PCOS) Polycystic Ovary Syndrome, Resistance, Insulin