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BACKGROUND Objectives-The present study was conducted to assess the effects of low dose Midazolam and continuous infusion of Propofol along with local anaesthesia in third molar surgeries to evaluate the level of sedation, haemodynamic changes, post-operative amnesia, condition of the patient during surgery, patient satisfaction and opinion. MATERIALS AND METHODS 25 ASA Grade I and II patients between the age group of 21 to 45 years, both male and female; who required surgical removal of third molars were selected. Patients received a low dose Midazolam bolus of 0.03 mg/kg prior to Propofol bolus of 0.7 mg/kg followed by continuous infusion of Propofol at 50 microgram/kg/min. Haemodynamic and respiratory parameters were monitored and recorded pre-operatively, intra-operatively and post-operatively at different time intervals. The level of sedation, amnesia and conditions of each patient were evaluated during the study. Patient's satisfaction was recorded using a modified Visual Analogue Scale (VAS). All results were evaluated statistically. RESULTS Haemodynamic and respiratory parameters remained stable throughout the procedures. The level of sedation for 75% patients had a sedation score of 3 during the operative procedure. Patient condition was rated excellent during the operative procedure in 72% patients by the surgeon. The psychomotor functions had improved by 60th minute postoperatively. CONCLUSION Conscious sedation using a low dose Midazolam with continuous infusion of Propofol along with local anaesthesia is a good and safe option for third molar surgeries as it produces superior quality sedation without serious complications.

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Background: Historically bupivacaine was used as it had a long duration of action, but subsequently it was found that "propyl derivatives" of pipecoloxylidides were less toxic than 'butyl derivatives' (bupivacaine). Thus ropivacaine was developed after bupivacaine was noted to be associated with significant number of cardiac arrests. Subjects and Methods: A comparative study of plain and hyperbaric solution of ropivacaine for spinal anaesthesia in minor gynaecological and urological procedures was undertaken in 60 patients. Patients were randomized in to two groups with 30 patients in Group H (2ml of 0.75% plain ropivacaine and 1ml of 25% dextrose) and 30 patients in Group P (2ml of 0.75% ropivacaine and 1ml of 0.9% normal saline). The onset and duration of sensory and motor blockade, sensory level achieved, and haemodynamic parameters were assessed. Results: The mean age of patients in group H was 45.83 ± 5.43 years compared to 45.76 ± 6.97 years in group P. In group H there were 11 males (37%) and 19 females (63%). In group P there were 10 males (33%) and 20 females (67%). The mean height of the patients in group H was 157.20 ± 5.06 cms and in group P was 159.70 ± 7.78 cms. The mean weight of the patients in group H was 56.63 ± 6.46 kgs and in group was 59.07 ± 7.53. There was no statistically significant difference between the two groups with regard to age, sex, height and weight (p>0.05). Both the groups were comparable with respect to age, sex, height and weight distribution. Conclusion: There was no significant change in systolic blood pressure following subarachnoid block in both groups. The systolic blood pressure values were comparable in both groups without any clinical or statistical significance.