BACKGROUND Objectives-The present study was conducted to assess the effects of low dose Midazolam and continuous infusion of Propofol along with local anaesthesia in third molar surgeries to evaluate the level of sedation, haemodynamic changes, post-operative amnesia, condition of the patient during surgery, patient satisfaction and opinion. MATERIALS AND METHODS 25 ASA Grade I and II patients between the age group of 21 to 45 years, both male and female; who required surgical removal of third molars were selected. Patients received a low dose Midazolam bolus of 0.03 mg/kg prior to Propofol bolus of 0.7 mg/kg followed by continuous infusion of Propofol at 50 microgram/kg/min. Haemodynamic and respiratory parameters were monitored and recorded pre-operatively, intra-operatively and post-operatively at different time intervals. The level of sedation, amnesia and conditions of each patient were evaluated during the study. Patient's satisfaction was recorded using a modified Visual Analogue Scale (VAS). All results were evaluated statistically. RESULTS Haemodynamic and respiratory parameters remained stable throughout the procedures. The level of sedation for 75% patients had a sedation score of 3 during the operative procedure. Patient condition was rated excellent during the operative procedure in 72% patients by the surgeon. The psychomotor functions had improved by 60th minute postoperatively. CONCLUSION Conscious sedation using a low dose Midazolam with continuous infusion of Propofol along with local anaesthesia is a good and safe option for third molar surgeries as it produces superior quality sedation without serious complications.