An efficient method for the CF3‐carbenoid C–H functionalization of benzenes and indoles using readily available methyl 3,3,3‐trifluoro‐2‐diazopropionate as a cross‐coupling partner under chelation‐controlled RhIII catalysis has been developed. The reactions proceeded smoothly with high regioselectivity in a few hours and allowed the simultaneous introduction of CF3 and carboxylate functions into the 2‐position of directing‐group‐containing benzenes and indoles.

An efficient method for the CF3‐carbenoid C‐7 functionalization of N‐pyrimidylindolines has been developed. This protocol uses readily available methyl 3,3,3‐trifluoro‐2‐diazopropionate as a cross‐coupling partner and smoothly proceeds under chelation‐controlled RhIII catalysis. The reactions provide the indoline products with high regioselectivity within a few hours and allow for the introduction of both the CF3 and carboxylate functions at the C‐7 position.

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CF 3-Carbenoid C-H Functionalization of (Hetero)arenes under Chelation--Controlled Rh III Catalysis. -An efficient method for the Rh(III)-catalyzed CF3--carbenoid C-H functionalization of benzenes and indoles bearing a directing group is presented. The regioselectivity can be switched by changing the catalytic system. -(IAGAFAROVA, I. E.; VOROBYEVA, D. V.; PEREGUDOV, A. S.; OSIPOV*, S. N.; Eur. J. Org. Chem. 2015, 22, 4950-4955, http://dx.