Sarcoidosis is a chronic multisystem inflammatory disease characterized by non-caseous granulomas, most commonly in the lungs and intrathoracic lymph nodes. The nasopharyngeal disease is a rare localization of sarcoidosis. Clinical presentations include difficulty in nasal breathing, rhinophonia, and postnasal syndrome. Nasopharyngeal endoscopy, computed tomography, and magnetic resonance imaging are the main diagnostic methods for detecting lesions in this area. The histological examination provides the diagnosis verification. Considering the frequent secondary spread of sarcoidosis, all patients should consult a rheumatologist to select adequate systemic therapy. We provide a clinical case illustrating the management of a patient with nasopharyngeal sarcoidosis.

A violation of cerebral circulation, in which a blood clot forms in the venous system of the brain with the formation of an obstruction of the dural sinus, one or more veins of the brain is called cerebral venous thrombosis. Cerebral venous sinus thrombosis (CVT) is a rare venous thromboembolic event, which accounts for 5 cases per 1 million among adults and about 7 cases per 1 million among children, according to the International Study on Cerebral Vein and Dural Sinus Thrombosis. Women of childbearing age are more susceptible to the disease, which is probably due to hormonal changes during pregnancy, labor, as well as the concomitant effect of oral contraceptives (leading to hypercoagulation). In addition to the low prevalence of CVT, the variety of etiology, the diagnosis is complicated by the highly variable clinical picture of cerebral venous thrombosis. The clinical manifestations of CVT are very diverse and depend on the prevalence of thrombosis, the rate of formation of vein occlusion, the age of patients, and the etiological factor. The main symptom of CVT is an intense headache (92%) as a sign of developing intracranial hypertension. During more than 2 years of follow-up, the mortality rate from CVT was calculated 8.3%, however, in more than 90% of cases the prognosis of the disease is favorable. Despite the favorable prognosis, without timely treatment of CVT, this is a potentially lethal disease, so the relevance of this topic is beyond doubt.

The original desire of all people is the desire to look more attractive by improving their appearance and the most advanced direction, in achieving aesthetic superiority, cosmetic surgical interventions have been and remain. The leading place in the patient’s desires is occupied by aesthetic facial surgery, where the most popular and not always justified is the change in the shape of the external nose. To date, the techniques and techniques for performing aesthetic rhinoplasty have reached their perfection. But at the stage of selecting patients for aesthetic surgery on the external nose, doctors always face certain difficulties. The most common problems for plastic surgeons are created by patients with dysmorphophobia where, for example, the main motive for persons with dysmorphomania to make rhinoplasty is dissatisfaction with the size and shape of their own nose, which, in their opinion, prevents them from achieving success in their personal life, building a career, etc. Other patients with dysmorphophobic syndrome have low self-esteem, in their opinion, the ugly shape of the nose prevents marriage etc. In this context, an unsuccessful example of performing aesthetic rhinoplasty for a patient whose anamnesis was aggravated by polypous rhinosinusitis and bronchial asthma with an uncontrolled course is given. A brief review of the literature and presented clinical examples substantiate the need to address a number of important questions at the stages of selection and planning of aesthetic rhinoplasty: does the patient have mental disorders; what are the true reasons motivating the patient for surgery; whether there are any diseases of the upper respiratory tract, violations of the architectonics of the deep sections of the nasal cavity, preventing operations, etc.