Оценка результативности дидактической модели формирования правовой экологической грамотности студентов технического вуза Статья посвящена актуальной на сегодняшний день проблеме формирования правовой экологической грамотности студентов в условиях образовательной среды технического вуза, вопросам усвоения и практического применения правовых экологических знаний. Основное внимание в работе авторы уделяют оценке результативности разработанной ими дидактической модели формирования правовой экологической грамотности.Наиболее значительные изменения после проведенной экспериментальной работы произошли по показателям личностного критерия, что свидетельствует о высокой способности студентами технического вуза постигать значение правовой экологической грамотности, о потребности постоянно следить за развитием теории и практики правовой экологической грамотности, о самосовершенствовании в области правовой экологической грамотности, о стремлении применять правовые экологические знания во взаимодействии со всеми субъектами образовательной среды, о повышении самоконтроля за соблюдением нормативно-правовых актов в сфере образования.Полученные сведения по итогам проведенной экспериментальной работы по апробации и практической реализации разработанной дидактической модели формирования правовой экологической грамотности студентов в условиях образовательной среды технического вуза позволяют констатировать ее результативность.Ключевые слова: дидактическая модель, оценка результативности, правовая экологическая грамотность, экологическая образовательная среда, критерии оценки правовой грамотности Перспективы Науки и Образования Международный электронный научный журнал

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Integration sites for HTLV-1 and HIV-1proviruses were detected by FISH on the chromosomes of HTHIV27 cells persistently infected by HIV-1 (strain IIIB). HTLV-1 signals were found on 9 loci of chromosomes 4, 6, 9, 15 and 16. Integration sites of GC-rich HTLV-1 provirus are located in GC-rich isochores, confirming an 'isopycnic' integration, namely an integration in which the GC level of the host sequences around the integration site match the GC level of the provirus. This conclusion is not only derived from the compositional map of human chromosomes, but also from HTLV-1 hybridization on compositional fractions of human DNA. Integration of GC-poor HIV-1 provirus was found on 4 loci of chromosomes 2, 7, 17 and 19. One copy of a complete HIV-1 provirus, which is active, was integrated in H1 isochores, whereas other defective copies were located in GC-poor L isochores. These results are discussed in terms of regional integration of retroviral sequences.

BACKGROUND. The number of organ transplantation surgeries is growing every year, including heart transplantion. The full spectrum of infections in heart transplant recipients is not well understood. One of the infectious agents that is particularly difficult to recognize is Toxoplasma gondii (T. gondii). AIM: This work determines the informative value of detecting laboratory markers of toxoplasmosis in patients after heart transplantation to identify active forms of invasion. MATERIALS AND METHODS: This investigation studied 121 heart recipients (95 men and 26 women) at different times after transplantation (several days to 12 years). Markers of Toxoplasma invasion were determined in blood sera, namely antibodies of the IgG, IgM, and IgA classes to T. gondii, avidity index of IgG antibodies to T. gondii, and DNA of the pathogen. RESULTS: In 60 patients (49.64.5%) after heart transplantation, markers of Toxoplasma invasion were identified. In 20 (16.53.6%) cases, markers of active invasion were revealed, namely IgM and IgA antibodies to T. gondii in six and 11 patients, respectively, low-grade IgG antibodies to T. gondii in three patients, and DNA of the pathogen in two cases. Based on the totality of studies, it was determined that the disease activity in 75% of cases was due to its reactivation, whereas in the other cases, it was a recent infection. Laboratory signs of toxoplasmosis reactivation occurred mainly during the first year after transplantation, which was probably associated with the intensity of immunosuppressive therapy. CONCLUSIONS: It was revealed that the most compelling studies indicating early signs of toxoplasmosis reactivation include detection of IgA antibodies to T. gondii and DNA of the pathogen. Further joint research is required by clinicians, epidemiologists, and laboratory diagnostics specialists to study the aspects of toxoplasmosis and disease diagnostics and preventionin patients after heart transplantation.