Detection of MDM2/CDK4 protein overexpression by IHC can be used by pathologists to diagnose WDLPS and DDLPS. Considering a strong and diffuse immunostaining pattern in most of the neoplastic cells achieves the best results in identifying these tumours.

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Introduction: Male sexual dysfunction (DSM) is characterized by changes in qualitative or quantitative sexual capacity, manifested by changes in ejaculation, erection, and/or orgasm, in addition to the presence of pain or discomfort in sexual relations, and the main one of these is erectile dysfunction (ED). Objective: Review the literature on sexual dysfunction caused by neurological disorders, in men aged 19 to 44 years. Methodology: This is a narrative literature review. The collection of information about the theme was carried out through a search for scientific articles in the PubMed databases. The descriptions used in the search were “sexual dysfunction AND neurological disorders in men”, articles published in the last 5 years were considered. Results: Several neurological diseases with a very high correlation with DSM were found, such as: multiple sclerosis, ED being the main problem reported by patients, depression and its respective treatment, epilepsy, mainly associated with anxiety and depression, Parkinson’s disease, spinal cord injury, spina bifida, stroke and traumatic brain injury, especially when associated with diabetic neuropathy. Conclusion: DS is a very frequent problem in neurological diseases, therefore, there is a need for this theme not to be neglected by health professionals, emphasizing the importance of multidisciplinary treatment. Mersh Terms: Impotence, Male Sexual Impotence, Nervous System Disease.

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