Summary The current global trend towards green and environmentally sustainable food sources has favoured plant‐based foods over animal‐based food products. Plants supply most of the required energy for the sustenance of all life forms on earth, and their health‐promoting qualities are mostly derived from their extracts and protein components, which make plant‐based bioactive peptides (BPs) great human health contributors. So many biological activities of these BPs have been reported in vitro but their demonstrated effects may not be the same as those found in in vivo studies. Therefore, this review is aimed at exploring recent literature on the demonstrated in vivo bioactivities of plant‐based BPs. The production of the peptides together with in vivo shreds of evidence are presented and their biological activities like antihypertensive, neuroprotective, and antioxidant effects are exemplified. Furthermore, some of the BP's mechanism of action along with their bioaccessibility inferences are described. Further considerations and concluding remarks on the therapeutic and commercialization potentials of plant‐based BPs are discussed.

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Summary Meat‐derived peptides (MDPs) through enzymatic hydrolysis possess an excellent potential for functional foods development except that their safety has always been a major concern. In this review, diligent efforts were made to provide the most updated perspectives on MDPs from multifarious sources, their biological activities and safety issues. In addition to these parameters, their production and market challenges were discussed. High costs involved, poor sensorial qualities, instability, and limited toxicologic and clinical data pose significant challenges to developing functional foods based on MDPs. To ensure the safety of these bioactive peptides and their commercial applications, digestibility, absorbability, metabolism, bioavailability and excretory studies should be considered in preclinical and clinical settings. Further studies in this line of research are of great importance.