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Despite advancement in tumors treatment, oral cancer has a poor prognosis and is often detected at late stage. Recent advancement in metagenomic technologies may be useful in identifying oral tumors–related microbiome, their genomes, virulence properties, and their interaction with host immunity. Alteration in the oral commensal microbial communities have potential application as a diagnostic tool to predict oral tumors. To develop highly precise and effective therapeutic approaches, identification of specific oral microbiomes may be required. In this review, we narrate the role of microbiome in the progression of oral tumors and its role as an early diagnostic and prognostic biomarker for oral tumors.

The aim of this study was to study the impact of Tumor Necrosis Factor-α (TNF-α) levels on dental caries demage in children with malignant tumors undergoing radiotherapy in the head and neck region. The case-control study included 48 children aged between 1 to 18 years divided into 2 identical groups by structure. The research group (Gr1) consisted of 24 children with malignant tumors in the head and neck region at a distance of 6 months - 2 years after the completion of radiotherapy (RT). 24 conventionally healthy children were included in the control group (Gr0). Were studied indications of carious experience, and the prediction of dental caries (DC) and the complex assessment of caries risk was performed with the application of Software Cariogram . TNF-α in oral fluid (OF) and blood serum was assessed by the method of immunoenzymatic on solid support. The analysis of the results of the study elucidated the high level of TNF-α in OF (5.53 times) and blood serum (10.19 times) of children with malignant tumors after completion of RT, compared to healthy subjects.Conclusions. Assessing the level of TNF-α in oral fluid and blood serum, in combination with other prognosis of dental caries, is an informative and important method in the early prediction of DC and the intense degree of activity of the caries process, necessary for the correction of preventive and treatment measures on the DC.

The scope of this work is to examine peculiarities of the free crystallogenesis in children with dental caries and inflammatory periodontal diseases, with application of classical methods of crystallography. To solve the task we conducted study of the oral fluid at 200 healthy children and 112 children with dental caries and inflammatory periodontal diseases. In this work is examined and made the comparative analysis of the change of structure of saliva`s facies in children with dental caries and inflammatory periodontal diseases. Results of the study: the level of microcrystallization of the children's saliva is directly correlated to the length (rxy= +0.647) and less to the gravity of the illness of dental caries and inflammatory periodontal diseases (rxy = +0.248). Crystallographic methods of study are able to carry not only diagnostical functions, but also to serve as sensitive indicator of the functional state of the human body in health and disease. Keywords: microcrystallization of the oral fluid, dental caries, inflammatory periodontal diseases.I.