The cell wall of Saccharomyces cerevisiae is an extracellular organelle crucial for preserving its cellular integrity and detec ng environmental cues. The cell wall is composed of mannoproteins a ached to a polysaccharide network and is con nuously remodeled as cells undergo cell division, ma ng, gametogenesis or adapt to stressors. This makes yeast an excellent model to study the regula on of genes important for cell wall forma on and maintenance. Given that certain yeast strains are pathogenic, a be er understanding of their life cycle is of clinical relevance. This is why transcrip onal regulatory mechanisms governing genes involved in cell wall biogenesis or maintenance have been the focus of numerous studies. However, li le is known about the roles of long non-coding RNAs (lncRNAs), a class of transcripts that are thought to possess li le or no protein coding poten al, in controlling the expression of cell wall-related genes. This review outlines currently known mechanisms of lncRNAmediated regula on of gene expression in S. cerevisiae and describes examples of lncRNA-regulated genes encoding cell wall proteins. We suggest that the associa on of currently annotated lncRNAs with the coding sequences and/or promoters of cell wall-related genes highlights a poten al role for lncRNAs as important regulators of the yeast cell wall structure.

No abstract