In ESKD patients undergoing hemodialysis, vitamin E supplementation significantly improved the HDL function of CEC and, in diabetic patients, endothelial function. These effects were independent of Hp phenotype.
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Calcitonin (CT) is a peptide hormone synthesized and secreted by the parafollicular (C) cells of the thyroid. Little is known about the mechanisms controlling proliferation of C cells by other humoral factors including CT, and there is no report that CT suppresses C cell proliferation. The effects of short-term administration of CT on C cell growth fraction were analyzed using BrdU and CT double immunohistochemical method in the rat thyroid. Continuous administration of 0.4 IU/kg and 40 IU/kg synthetic salmon CT for 14 days induced dosedependent suppression of BrdU labeling number of C cells without decrease of C cell to the total thyroid follicular cell ratio. These results suggest that exogenous CT may induce negative feedback to C cell proliferation in the thyroid.

After a 9‐week immunization period, all the livers in inbred C57BL/6 mice immunized with syngeneic crude liver protein (LSN) in Freund's complete adjuvant showed histological changes mainly in the portal areas. Morphological features and the subsequent in vitro and in vivo data suggested that the principal histological changes were due to extramedullary hemopoiesis and not to autoimmune hepatitis. This is the first description of extramedullary hemopoiesis in studies concerning experimental autoimmune hepatitis. The significance of our findings is, first, that the occurrence of hepatic hemopoiesis induced by the usual immunization method necessitates morphologically distinct evidence of inflammation to be a prerequisite in studies of experimental autoimmune hepatitis. Without this proof, subsequent investigations would be confusing. Second, immunization can be added to a variety of conditions to induce hepatic hemopoiesis. This would provide a convenient and interesting tool for application to further studies of hemopoiesis. ACTA PATHOL JPN 38: 1105∼1118, 1988.

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