Vitamin E supplementation improves high-densitiy lipoprotein and endothelial functions in end-stage kidney disease patients undergoing hemodialysis

Mune, Masatoshi; Uto‐Kondo, Harumi; Iteya, Iwao; Fujii, Yasuhisa; Ikeda, Shoichiro; Ikewaki, Katsunori

doi:10.5414/cn109197

Cited by 11 publications

(9 citation statements)

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“…As previously reported, supplementation of -tocopherol increased CEC in patients with end-stage renal disease 11) , a finding consistent with that in patients with type 1 diabetes 12) . CEC changes correlated positively with serum -tocopherol and -tocopherol in this study.…”

Section: Discussionsupporting

confidence: 89%

“…Therefore, improving CEC of HDL particles, rather than increasing HDL-C levels, is considered to be a novel target for the prevention of CVD. Although HDL has been shown to have antioxidant properties 7,8) and certain antioxidant foods reportedly increase CEC 9,10) , there have been few studies focusing on the relationships of CEC with oxygen radical absorbance capacity (ORAC) and lipophilic dietary antioxidant levels in serum 11,12) .…”

Section: Introductionmentioning

confidence: 99%

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Effects of Dietary Education Program for the Japan Diet on Cholesterol Efflux Capacity: A Randomized Controlled Trial

Umezawa

Maruyama

Endo

et al. 2022

JAT

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Improving cholesterol efflux capacity (CEC) of high-density lipoprotein (HDL) has been regarded as a novel target for preventing cardiovascular disease. HDL reportedly has antioxidant properties which may contribute to its functions. We investigated changes in CEC with intake of the Japan Diet (JD) recommended by the Japan Atherosclerosis Society and the relationship of these changes to serum antioxidant concentrations.Methods: A randomized parallel controlled clinical trial on JD intake was performed in Japanese patients with dyslipidemia. Ninety-eight participants were randomly divided into the JD (n 49) or the partial JD (PJD) (n 49) group. Nutrition education, based on each diet at baseline and at 3 months, was provided and the participants were followed up for 6 months.Results: Mean CEC was 1.05 in total and correlated positively with HDL-cholesterol (p 0.001) at baseline. CEC did not change while oxygen radical absorbance capacity (ORAC) was decreased in both groups (p 0.001). Although serum total carotenoid increased in both groups, serum -tocopherol decreased in the JD group as compared to the PJD group (p 0.05). CEC correlated positively with HDL ORAC at baseline (p 0.021) and with serum total carotenoid at 3 and 6 months (p 0.005, 0.035). Changes in CEC correlated positively with changes in HDL ORAC at 3 months and serum total tocopherol at 3 and 6 months (p 0.001). Conclusion:CEC was not changed by JD education in Japanese patients with dyslipidemia who already had normal CEC at baseline. CEC was suggested to be positively associated with serum -and -tocopherol and HDL ORAC.high HDL-C concentrations lead to CVD risk reduction has been challenged by intervention studies [2][3][4] . Cholesterol efflux capacity (CEC) is one of the major functions of HDL, which contributes to the first step of the reverse cholesterol transport pathway by promoting efflux of excess cellular cholesterol.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Education Program for the Japan Diet on Cholesterol Efflux Capacity: A Randomized Controlled Trial

Umezawa

Maruyama

Endo

et al. 2022

JAT

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“…It has been shown in in vitro, in vivo and clinical studies that antioxidants activate the NO/eNOS pathway through decreasing in the amount of ROS [ 56 , 57 , 58 ]. Several lines of evidence have shown that antioxidants including vitamin E [ 59 , 60 , 61 , 62 ], vitamin B12 [ 63 ], alpha-lipoic acid [ 62 ], N-acethlcystein [ 64 , 65 ], flaxseed [ 66 ], L-carnitine [ 67 ], catechins [ 68 ], coenzyme Q10 [ 69 ], pycnogenol [ 70 ], and chlorogenic acids [ 71 ] improve or augment endothelial function in patients with CVD and in subjects who have cardiovascular risk factors as well as healthy subjects. However, not all of the studies showed the beneficial effects of antioxidants on endothelial function [ 72 , 73 , 74 , 75 , 76 ].…”

Section: Oxidative Stressmentioning

confidence: 99%

Roles of Oxidative Stress and Inflammation in Vascular Endothelial Dysfunction-Related Disease

Higashi

2022

Antioxidants

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Oxidative stress and chronic inflammation play an important role in the pathogenesis of atherosclerosis. Atherosclerosis develops as the first step of vascular endothelial dysfunction induced by complex molecular mechanisms. Vascular endothelial dysfunction leads to oxidative stress and inflammation of vessel walls, which in turn enhances vascular endothelial dysfunction. Vascular endothelial dysfunction and vascular wall oxidative stress and chronic inflammation make a vicious cycle that leads to the development of atherosclerosis. Simultaneously capturing and accurately evaluating the association of vascular endothelial function with oxidative stress and inflammation would be useful for elucidating the pathophysiology of atherosclerosis, determining treatment efficacy, and predicting future cardiovascular complications. Intervention in both areas is expected to inhibit the progression of atherosclerosis and prevent cardiovascular complications.

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“…Antioxidant supplementation in subjects with nephropathy has shown promising results in slowing progression of atherosclerosis: Even a short-term, low dose, vitamin E supplementation (almost 300 mg/die) seems to improve, in patients with ESRD undergoing hemodialysis, the flow-mediated arterial dilation (FMD), an indirect method to assess the endothelial function [22]. These vascular effects could mediate the protective role of tocopherols and tocotrienols on DKD.…”

Section: Diabetic Nephropathy and Vitamin Ementioning

confidence: 99%

Antioxidant, Anti-Inflammatory, and Metabolic Properties of Tocopherols and Tocotrienols: Clinical Implications for Vitamin E Supplementation in Diabetic Kidney Disease

Vincenzo

Tana

et al. 2019

IJMS

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Diabetes mellitus is a metabolic disorder characterized by the development of vascular complications associated with high morbidity and mortality and the consequent relevant costs for the public health systems. Diabetic kidney disease is one of these complications that represent the main cause of end-stage renal disease in Western countries. Hyperglycemia, inflammation, and oxidative stress contribute to its physiopathology, and several investigations have been performed to evaluate the role of antioxidant supplementation as a complementary approach for the prevention and control of diabetes and associated disturbances. Vitamin E compounds, including different types of tocopherols and tocotrienols, have been considered as a treatment to tackle major cardiovascular outcomes in diabetic subjects, but often with conflicting or even negative results. However, their effects on diabetic nephropathy are even less clear, despite several intervention studies that showed the improvement of renal parameters after supplementation in patients with diabetic kidney disease. Then we performed a review of the literature about the role of vitamin E supplementation on diabetic nephropathy, also describing the underlying antioxidant, anti-inflammatory, and metabolic mechanisms to evaluate the possible use of tocopherols and tocotrienols in clinical practice.

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Vitamin E supplementation improves high-densitiy lipoprotein and endothelial functions in end-stage kidney disease patients undergoing hemodialysis

Abstract: In ESKD patients undergoing hemodialysis, vitamin E supplementation significantly improved the HDL function of CEC and, in diabetic patients, endothelial function. These effects were independent of Hp phenotype. .

Cited by 11 publications

References 0 publications

Effects of Dietary Education Program for the Japan Diet on Cholesterol Efflux Capacity: A Randomized Controlled Trial

Effects of Dietary Education Program for the Japan Diet on Cholesterol Efflux Capacity: A Randomized Controlled Trial

Roles of Oxidative Stress and Inflammation in Vascular Endothelial Dysfunction-Related Disease

Antioxidant, Anti-Inflammatory, and Metabolic Properties of Tocopherols and Tocotrienols: Clinical Implications for Vitamin E Supplementation in Diabetic Kidney Disease

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Vitamin E supplementation improves high-densitiy lipoprotein and endothelial functions in end-stage kidney disease patients undergoing hemodialysis

Abstract: In ESKD patients undergoing hemodialysis, vitamin E supplementation significantly improved the HDL function of CEC and, in diabetic patients, endothelial function. These effects were independent of Hp phenotype. .

Cited by 11 publications

References 0 publications

Effects of Dietary Education Program for the Japan Diet on Cholesterol Efflux Capacity: A Randomized Controlled Trial

Effects of Dietary Education Program for the Japan Diet on Cholesterol Efflux Capacity: A Randomized Controlled Trial

Roles of Oxidative Stress and Inflammation in Vascular Endothelial Dysfunction-Related Disease

Antioxidant, Anti-Inflammatory, and Metabolic Properties of Tocopherols and Tocotrienols: Clinical Implications for Vitamin E Supplementation in Diabetic Kidney Disease

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Abstract: In ESKD patients undergoing hemodialysis, vitamin E supplementation significantly improved the HDL function of CEC and, in diabetic patients, endothelial function. These effects were independent of Hp phenotype. .