Supersonic cavity flows driven by a thick shear layer at Mach 1·5 and 2·5 are studied by solving the two-dimensional unsteady compressible Navier-Stokes equations in terms of mass-averaged variables. The length to depth ratio of the rectangular cavity is three. The numerical scheme used is the finite-difference algorithm by Brailovskaya. A two-layer eddy-viscosity turbulence model is used. The results are compared with experimental data. The computations show the self-sustained oscillations at Mach 1·5 and 2·5. The continuous formation and downstream shedding of leading edge vortices is demonstrated. The oscillatory modes are correctly predicted. The first mode is attributed to a large unsteady trailing edge vortex moving in the transverse direction. Based on the analysis, it is considered that the oscillation in the length to depth ratio three cavity is a longitudinal one and is controlled by a fluid dynamic mechanism rather than a purely acoustic one.

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Erythroid cell iron uptake and globin synthesis were studied in the anemia of the Belgrade Laboratory rat (gene symbol, b), an autosomal recessive trait characterized by hypochromia and hyperferrinemia. Reticulocyte protein and globin synthesis, as measured in vitro by the incorporation of 3H-L-leucine, were significantly diminished in b/b animals, although no major imbalance between alpha-and beta-chain production was observed in b/b reticulocytes. The incorporation in vitro of 3H-L-methionine into marrow cell globin demonstrated no difference between b/b animals and +/? control animals in the proportion of alpha-to beta-chain production. The transfer of iron from plasma to reticulocytes, as measured in vitro by the uptake of 59Fe, was significantly decreased in b/b animals; Sephadex G 200 chromatography of b/b red cell lysates did not reveal the accumulation of 59Fe in nonhemoglobin fractions found when heme synthesis was inhibited with isoniazid. The magnitude of the reticulocyte iron-uptake defect was greater than the reticulocyte globin-synthesis defect, suggesting that the former is the primary lesion.

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