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ABSTRACT:Macrolides are an old, well established class of antibacterial agents which play an important role in the management of infectious diseases. The present study was undertaken to study the CNS effects of some of the macrolides antibiotics namely erythromycin, clarithromycin, azithromycin and roxithromycin in rats. 30 healthy adult albino rats of either sex of Haffkine's strain weighing 100-200g were used for the study. Each group consists of six animals. Various tests were used for screening of drugs on CNS activity. Amongst the macrolides namely erythromycin claritromycin, azithromycin and roxithromycin, only roxithromycin showed CNS depressant activity in rats. Similarly only roxithromycin and azithromycin showed anti-inflammatory property.

HAART, consisting of two nucleoside reverse transcriptase inhibitors and one non-nucleoside reverse transcriptase inhibitor, was instituted. The initial therapy in majority of subjects was zidovudine (AZT)+lamivudine (3TC)+nevirapine (NVP). AZT was substituted by tenofovir disoproxil (TDF) in patients with Hb< 9 gm%, whereas NVP was substituted by efavirenz (EFV) in

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