Background: Puerperal sepsis is among the leading cause of preventable maternal morbidity and mortality not only in developing countries but in developed countries as well. This study was undertaken to isolate and identify aerobic bacterial agents of puerperal sepsis among the patients admitted in rural medical college of Maharashtra. Methods: Blood samples were collected from 67 cases of Puerperal sepsis and were cultured aerobically. The organisms were identified by standard biochemical tests. Antimicrobial sensitivity testing done by Kirby Bauer disc diffusion method. Results: Out of 67 samples, 46 (68.65%) yielded growth in blood culture. The isolated organisms were Klebsiella aerogenes, Staph. aureus, Pseudomonas aeruginosa, Proteus, E. coli, Streptococcus pyogenes and coagulase negative Staphylococci. Most of the organisms are resistant to commonly used antibiotics such as ampicillin, penicillin and amikacin. Conclusions: Puerperal sepsis is the common life threatening condition in the postnatal period, particularly following vaginal delivery. Early diagnosis and appropriate treatment of puerperal sepsis can make the difference between life and death.

The purpose of this study was to determine student perceptions of the methods used to teach pharmacology via problem-based learning (PBL

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Background: This study was designed to investigate the hypoglycemic effect of Tinospora Cordifolia in alloxan-induced diabetic rabbits. Methods: Rabbits were divided into four experimental groups: Non-diabetic rabbits treated with normal saline, Non-diabetic rabbits treated with TCREt, Diabetic rabbits treated with Metformin, Diabetic rabbits treated with TCREt. Treatment with drugs was started on the 8th day of alloxan treatment (i.e. day 1) and was continued for 30 days. Statistical evaluation was done using student’s ‘t’ test & one way ANOVA followed by Tuckey`s post hoc test. ‘p’ value less than 0.05 was considered statistically significant. Results: TCREt showed hypoglycemic action in alloxan induced diabetes rabbits. It did not produce hypoglycemia in non diabetic rabbits. Conclusion: Hypoglycemic action of TCREt is comparable to that of standard oral hypoglycemic drug metformin. [Int J Basic Clin Pharmacol 2013; 2(5.000): 559-561

Background: Calcium channel blockers are amongst the commonly used drugs in the treatment of cardiovascular disorders. They produce their action by blocking voltage regulated calcium channels. Methodolgy: Present study evaluated the effects of three structurally dissimilar calcium channel blockers Nitrendipine (a dihydropyridine) in a single dose of 10 mg and 20 mg, Diltiazem (a benzothiazepine) in a single dose of 30 mg and 60 mg and Verapamil (a phenylalkylamine) in a single dose of 40 mg and 80 mg on psychomotor performance in human volunteers. For evaluation of psychomotor performance, the tests used were arithmetic ability, verbal learning, letter cancellation, digit symbol substitution and card sorting test. Results: Nitrendipine both in low dose (10mg) and high dose (20mg) as well as Diltiazem in high dose (60mg) and Verapamil in high dose (80mg) were found to impair the psychomotor performance in human volunteers to a statistically significant extent in all the tests employed except letter cancellation test. Whereas Diltiazem in low dose (30mg) and Verapamil in low dose (40mg) showed statistically significant impairment of psychomotor performance using arithmetic ability, verbal learning, and digit symbol substitution test. Conclusion: Thus calcium channel blockers namely Nitrendipine, Diltiazem and Verapamil significantly impaired the psychomotor performance of human volunteers in our study. DOI: http://dx.doi.org/10.3329/bjms.v12i1.11534 Bangladesh Journal of Medical Science Vol. 12 No. 01 January’13 pp.43-48