Throughout the Middle Ages, Dubrovnik maintained active and regular commercial and maritime contacts with various cities and states of the Mediterranean. These activities led to the organisation of a health care system and the development of medicine. With respect to the economic, commercial and maritime aspects of the culture of this city state, Dubrovnik became open to the civilising progress of the region and period. The brief visit of the Mediaeval ophthalmologist, Master Samuel Ebrej supports this fact.
Spermolithiasis has been a neglected subject of discussions and of published observations. This may be due to the fact that the process is fairly uncommon and does not seem to involve serious clinical consequences. It presents, on the other hand, important differential diagnostic aspects in connection with the pathology of the true pelvis and may give rise to misinterpretations unless its possibility is kept in mind. The importance of this rare syndrome is pointed out. Its etiology, pathology, symptomatology, differential diagnosis and therapy are discussed. Five observations are reported.
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