Tamsulosin is the most potent adrenergic alpha-1 antagonist used for the treatment of benign prostatic hyperplasia. Priapism has been reported rarely in patients taking Prazosin, Doxazosin and Terazosin. We describe an otherwise healthy man with recurrent and then persistent unresolved priapism after the use of tamsulosin. Initial treatment consisted of aspiration and intracavernosal irrigation of iced saline and vasoconstrictive agent, but in vain. We then performed Winters procedure but that too failed and the priapism persisted. Health-care professionals should inform all patients taking such medications about rare but possible serious adverse effects.

Squamous cell carcinoma is a rare neoplasm of the prostate gland, forming about 0.5 of all prostatic malignancies. We present a case of squamous cell carcinoma of the prostate. Squamous cell carcinoma is usually indistinguishable from adenocarcinoma of the prostate by clinical features. Diagnosis is by histological examination. There are definite criteria for diagnosis like keratinisation, epithelial pearls and intercellular bridges. The cell of origin is widely accepted as the transitional epithelium of the urethra and periurethral ducts. This tumour is biologically much more aggressive than adenocarcinoma. There is no treatment modality which offers satisfactory results and the survival time is short.

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