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Captopril was given to 42 hypertensive patients aged 1 to 17 years who were treated by regular haemodialysis because of terminal renal failure. Initially all patients were on antihypertensive treatment without sufficient control of blood pressure. Under captopril all patients presented a significant decrease of both systolic and diastolic blood pressures. The mean decrease of systolic blood pressure was from 162 to 114 and that of diastolic blood pressure from 106 to 86 mmHg. Plasma renin activity rose significantly in all cases whereas plasma aldosterone dropped and reached normal levels for age. The maximum effective dosage was 3 mg/kg/day. Total duration of treatment with captopril ranged from 1 1/2 to 6 1/12 (mean 3 2/12) years. At last observation the dosage of captopril varied between 0.3 and 3 mg/kg/day.

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Plasma levels of glucose, insulin and glucagon were measured at various time intervals after pancreatic duct ligation (PDL) in rabbits. Two hyperglycemic periods were observed: one between 15–90 days (peak at 30 days of 15.1 ± 1.2mmol/l, p < 0.01), and the other at 450 days (11.2 ± 0.5 mmol/l, p < 0.02). The first hyperglycemic episode was significantly correlated with both hypoinsulinemia (41.8 ± 8pmol/l, r= –0.94, p < 0.01) and hyperglucagonemia (232 ± 21ng/l, r=0.95, p < 0.01). However, the late hyperglycemic phase (450 days), which was not accompanied by hypoinsulinemia, was observed after the hyperglucagonemia (390 days) produced by abundant immunostained A-cells giving rise to a 3-fold increase in pancreatic glucagon stores. The insulin and glucagon responses to glucose loading at 180, 270 and 450 days reflected the insensitivity of B- and A-cells to glucose. The PDL rabbit model with chronic and severe glycemic disorders due to the predominant role of glucagon mimicked key features of the NIDDM syndrome secondary to exocrine disease.

Summary. a-amylase activity variations in the parietal and intraluminal contents of the digestive tract in control and pancreatic duct ligated rabbits. a-amylase activity (E.C.3.2.1 .1) was studied in the parietal and intraluminal contents of different parts of the digestive tract in control (T) and pancreatic duct ligated rabbits (P-). Maximal activity at the parietal level in control rabbits was observed in the median part of the duodenum (392 ! 37 fL M/maltose/g/min at 37 °C). Weak activity (3 p. 100 of the duodenal activity) was seen in other parts of the small and large bowel. Variations in a-amylase activity were noted in the post-ligature period in rabbits. This activity declined by 38 p. 100 2 weeks after ligature ; normal values reappeared 6 weeks later, and 10 weeks after the operation the values were 40 p. 100 higher than those of control rabbits. Maximal intraluminal content activity was observed in the jejunum and ileum of T rabbits (182 !26 and 92 ! 6 y m jmaltosejg jmin at 37 °C).The large bowel showed only 5 p. 100 of the jejunal activity. In P-rabbits, a-amylase activity progressively increased only in the large bowel from 2 and 6 weeks ( x 3) to 10 weeks ( x 6). Suppression of pancreatic digestion was followed by a compensative process. Hyperplasia and hypertrophy of Briinner's glands could explain the rise in a-amylase activity at the duodenal level. The elevation observed in intraluminal contents was certainly of bacterial origin.Il est connu que chez des animaux qui présentent des troubles pancréatiques, il apparaît souvent une variation des activités enzymatiques intestinales. Plus précisé-ment, dans le cas de déficience pancréatique exocrine, certains auteurs ont pu constater une élévation des hydrolases glucidiques, principalement des disaccharidases (Cerda, Preiser et Crane, 1972 ;Madzarovova-Nohejlova, 1976